Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A

Thrombin-induced cyclic AMP (cAMP) reduction potentates several steps in platelet activation, including Ca++ mobilization, cytoskeletal reorganization, and fibrinogen receptor conformation. We now reinvestigate the signaling pathways by which intracellular cAMP content is controlled after platelet a...

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Veröffentlicht in:	Blood 2007-09, Vol.110 (5), p.1475-1482
Hauptverfasser:	Zhang, Wei, Colman, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology 3',5'-Cyclic-AMP Phosphodiesterases - metabolism Adenylyl Cyclase Inhibitors Biological and medical sciences Blood Platelets - enzymology Calcium - metabolism Calcium Signaling - drug effects Calcium Signaling - physiology Cilostazol Cyclic AMP - metabolism Cyclic Nucleotide Phosphodiesterases, Type 3 Cytoskeleton - metabolism Enzyme Activation - drug effects Hematologic and hematopoietic diseases Hemostasis, Thrombosis, and Vascular Biology Hemostatics - pharmacology Humans Hydrolysis - drug effects Medical sciences Milrinone - pharmacology Phosphodiesterase Inhibitors - pharmacology Phosphoprotein Phosphatases - antagonists & inhibitors Phosphoprotein Phosphatases - metabolism Phosphorylation - drug effects Platelet Activation - drug effects Platelet Activation - physiology Protein Phosphatase 1 Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Purinergic P2 Receptor Antagonists Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2Y12 Tetrazoles - pharmacology Thrombin - pharmacology
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