Differences in vascular response between primary and transplanted tumours
The vast majority of studies on tumour vasculature are performed on transplanted tumours in rodents. However, it is known that there may be differences between primary and transplanted lesions. The purpose of this study is to test whether a specific vascular response is similar in primary tumours an...
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| Veröffentlicht in: | British journal of cancer 1991-05, Vol.63 (5), p.723-726 |
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| container_title | British journal of cancer |
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| creator | Field, SB Needham, S Burney, IA Maxwell, RJ Coggle, JE Griffiths, JR |
| description | The vast majority of studies on tumour vasculature are performed on transplanted tumours in rodents. However, it is known that there may be differences between primary and transplanted lesions. The purpose of this study is to test whether a specific vascular response is similar in primary tumours and in transplanted tumours derived from them. The technique used was to give an intraperitoneal injection of 5 mg kg-1 hydralazine, which is known to result in hypoxia in transplanted tumours. Changes in perfusion were indicated by changes in metabolism, monitored using 31P Magnetic Resonance Spectroscopy. The primary tumours were induced by local irradiation many months previously and only 4/11 (36%) of these responded to hydralazine. One of the non responders was subsequently transplanted into isogeneic mice to produce a tumour line which was histologically very similar to the primary. Of these 16/17 (94%) responded. The difference is statistically significant (P = 0.001). The reasons for this difference are not known. A number of possibilities are discussed and in the authors' opinion, the most likely cause is that it results from an artefact of transplantation. |
| doi_str_mv | 10.1038/bjc.1991.163 |
| format | Article |
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However, it is known that there may be differences between primary and transplanted lesions. The purpose of this study is to test whether a specific vascular response is similar in primary tumours and in transplanted tumours derived from them. The technique used was to give an intraperitoneal injection of 5 mg kg-1 hydralazine, which is known to result in hypoxia in transplanted tumours. Changes in perfusion were indicated by changes in metabolism, monitored using 31P Magnetic Resonance Spectroscopy. The primary tumours were induced by local irradiation many months previously and only 4/11 (36%) of these responded to hydralazine. One of the non responders was subsequently transplanted into isogeneic mice to produce a tumour line which was histologically very similar to the primary. Of these 16/17 (94%) responded. The difference is statistically significant (P = 0.001). The reasons for this difference are not known. A number of possibilities are discussed and in the authors' opinion, the most likely cause is that it results from an artefact of transplantation.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.1991.163</identifier><identifier>PMID: 1645562</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animal tumors. Experimental tumors ; Animals ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Drug Resistance ; Epidemiology ; Experimental tumors, general aspects ; experimental-oncology ; Fibroma - blood supply ; Fibrosarcoma - blood supply ; Histiocytoma, Benign Fibrous - blood supply ; Hydralazine - pharmacology ; Magnetic Resonance Spectroscopy ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Molecular Medicine ; Neoplasm Transplantation ; Neoplasms, Radiation-Induced - blood supply ; Oncology ; Phosphorus ; Regional Blood Flow - drug effects ; Skin Neoplasms - blood supply ; Skin Neoplasms - etiology ; Tumors</subject><ispartof>British journal of cancer, 1991-05, Vol.63 (5), p.723-726</ispartof><rights>Cancer Research Campaign 1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-33eaf644d1920d7941d56d749f2c3b3ef81e552e9523b94fa8d87d449dd5e17a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972409/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972409/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,2725,27922,27923,41486,42555,51317,53789,53791</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19770308$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1645562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Field, SB</creatorcontrib><creatorcontrib>Needham, S</creatorcontrib><creatorcontrib>Burney, IA</creatorcontrib><creatorcontrib>Maxwell, RJ</creatorcontrib><creatorcontrib>Coggle, JE</creatorcontrib><creatorcontrib>Griffiths, JR</creatorcontrib><title>Differences in vascular response between primary and transplanted tumours</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>The vast majority of studies on tumour vasculature are performed on transplanted tumours in rodents. However, it is known that there may be differences between primary and transplanted lesions. The purpose of this study is to test whether a specific vascular response is similar in primary tumours and in transplanted tumours derived from them. The technique used was to give an intraperitoneal injection of 5 mg kg-1 hydralazine, which is known to result in hypoxia in transplanted tumours. Changes in perfusion were indicated by changes in metabolism, monitored using 31P Magnetic Resonance Spectroscopy. The primary tumours were induced by local irradiation many months previously and only 4/11 (36%) of these responded to hydralazine. One of the non responders was subsequently transplanted into isogeneic mice to produce a tumour line which was histologically very similar to the primary. Of these 16/17 (94%) responded. The difference is statistically significant (P = 0.001). The reasons for this difference are not known. A number of possibilities are discussed and in the authors' opinion, the most likely cause is that it results from an artefact of transplantation.</description><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Experimental tumors, general aspects</subject><subject>experimental-oncology</subject><subject>Fibroma - blood supply</subject><subject>Fibrosarcoma - blood supply</subject><subject>Histiocytoma, Benign Fibrous - blood supply</subject><subject>Hydralazine - pharmacology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred CBA</subject><subject>Molecular Medicine</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms, Radiation-Induced - blood supply</subject><subject>Oncology</subject><subject>Phosphorus</subject><subject>Regional Blood Flow - drug effects</subject><subject>Skin Neoplasms - blood supply</subject><subject>Skin Neoplasms - etiology</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1LwzAYh4Moc05vXoVevNmZrzbNRZD5NRh40XNImzezo0tH0ir-92Z0bHrwFF5-T37vy4PQJcFTgllxW66qKZGSTEnOjtCYZIympKDiGI0xxiLFkuJTdBbCKo4SF2KERiTnWZbTMZo_1NaCB1dBSGqXfOpQ9Y32iYewaV2ApITuC8AlG1-vtf9OtDNJ57ULm0a7DuLQr9veh3N0YnUT4GL3TtD70-Pb7CVdvD7PZ_eLtOKCdiljoG3OuSHxLCMkJybLjeDS0oqVDGxBIMsoyIyyUnKrC1MIw7k0JgMiNJugu6F305drMBW4eE2jduepVtfqb-LqD7VsPxWRgnIsY8HNUFD5NgQPdv-XYLU1qqJRtTWqotGIX_3ed4AHhTG_3uVRnW5sVFPV4YBJITDDReTSgQsxckvwahW1uajqv73JwDvd9R72hRHaMlvkB6ZBmps</recordid><startdate>19910501</startdate><enddate>19910501</enddate><creator>Field, SB</creator><creator>Needham, S</creator><creator>Burney, IA</creator><creator>Maxwell, RJ</creator><creator>Coggle, JE</creator><creator>Griffiths, JR</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>19910501</creationdate><title>Differences in vascular response between primary and transplanted tumours</title><author>Field, SB ; Needham, S ; Burney, IA ; Maxwell, RJ ; Coggle, JE ; Griffiths, JR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-33eaf644d1920d7941d56d749f2c3b3ef81e552e9523b94fa8d87d449dd5e17a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animal tumors. Experimental tumors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Experimental tumors, general aspects</topic><topic>experimental-oncology</topic><topic>Fibroma - blood supply</topic><topic>Fibrosarcoma - blood supply</topic><topic>Histiocytoma, Benign Fibrous - blood supply</topic><topic>Hydralazine - pharmacology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred CBA</topic><topic>Molecular Medicine</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms, Radiation-Induced - blood supply</topic><topic>Oncology</topic><topic>Phosphorus</topic><topic>Regional Blood Flow - drug effects</topic><topic>Skin Neoplasms - blood supply</topic><topic>Skin Neoplasms - etiology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Field, SB</creatorcontrib><creatorcontrib>Needham, S</creatorcontrib><creatorcontrib>Burney, IA</creatorcontrib><creatorcontrib>Maxwell, RJ</creatorcontrib><creatorcontrib>Coggle, JE</creatorcontrib><creatorcontrib>Griffiths, JR</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Field, SB</au><au>Needham, S</au><au>Burney, IA</au><au>Maxwell, RJ</au><au>Coggle, JE</au><au>Griffiths, JR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences in vascular response between primary and transplanted tumours</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>1991-05-01</date><risdate>1991</risdate><volume>63</volume><issue>5</issue><spage>723</spage><epage>726</epage><pages>723-726</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>The vast majority of studies on tumour vasculature are performed on transplanted tumours in rodents. However, it is known that there may be differences between primary and transplanted lesions. The purpose of this study is to test whether a specific vascular response is similar in primary tumours and in transplanted tumours derived from them. The technique used was to give an intraperitoneal injection of 5 mg kg-1 hydralazine, which is known to result in hypoxia in transplanted tumours. Changes in perfusion were indicated by changes in metabolism, monitored using 31P Magnetic Resonance Spectroscopy. The primary tumours were induced by local irradiation many months previously and only 4/11 (36%) of these responded to hydralazine. One of the non responders was subsequently transplanted into isogeneic mice to produce a tumour line which was histologically very similar to the primary. Of these 16/17 (94%) responded. The difference is statistically significant (P = 0.001). The reasons for this difference are not known. A number of possibilities are discussed and in the authors' opinion, the most likely cause is that it results from an artefact of transplantation.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>1645562</pmid><doi>10.1038/bjc.1991.163</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animal tumors. Experimental tumors Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Drug Resistance Epidemiology Experimental tumors, general aspects experimental-oncology Fibroma - blood supply Fibrosarcoma - blood supply Histiocytoma, Benign Fibrous - blood supply Hydralazine - pharmacology Magnetic Resonance Spectroscopy Medical sciences Mice Mice, Inbred C57BL Mice, Inbred CBA Molecular Medicine Neoplasm Transplantation Neoplasms, Radiation-Induced - blood supply Oncology Phosphorus Regional Blood Flow - drug effects Skin Neoplasms - blood supply Skin Neoplasms - etiology Tumors |
| title | Differences in vascular response between primary and transplanted tumours |
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