Production of immunoreactive insulin-like growth factor-I (IGF-I) and IGF-I binding proteins by human lung tumours
The production of insulin-like growth factor I (IGF-I) and IGF-I binding proteins (BPs) by human lung tumour cell lines in vitro has been examined and the levels of these substances in the serum of lung cancer patients investigated. While small cell lung cancer (SCLC) cell lines secreted both IGF-I...
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| Veröffentlicht in: | British journal of cancer 1990-05, Vol.61 (5), p.727-731 |
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| container_title | British journal of cancer |
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| creator | REEVE, J. G PAYNE, J. A BLEEHEN, N. M |
| description | The production of insulin-like growth factor I (IGF-I) and IGF-I binding proteins (BPs) by human lung tumour cell lines in vitro has been examined and the levels of these substances in the serum of lung cancer patients investigated. While small cell lung cancer (SCLC) cell lines secreted both IGF-I and BPs, non-small cell lung cancer (NSCLC) cell lines secreted BPs only. No evidence of increased serum IGF-I levels was obtained in a cohort of 52 lung cancer patients having SCLC and NSCLC histologies. In contrast, serum levels of low molecular weight BPs were markedly elevated in the majority of lung cancer patients. |
| doi_str_mv | 10.1038/bjc.1990.163 |
| format | Article |
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In contrast, serum levels of low molecular weight BPs were markedly elevated in the majority of lung cancer patients.</description><subject>Biological and medical sciences</subject><subject>Carcinoma, Non-Small-Cell Lung - metabolism</subject><subject>Carcinoma, Small Cell - metabolism</subject><subject>Carrier Proteins - metabolism</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor Binding Proteins</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Lung Neoplasms - metabolism</subject><subject>Medical sciences</subject><subject>Pneumology</subject><subject>Somatomedins - metabolism</subject><subject>Tumor Cells, Cultured - metabolism</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFvFCEUxonR1LV682rCwRhNnPoYZmC4mDSNrZs00YOeCQPMLnUGVhja9L-XcTerPfUE730_vvfIh9BrAmcEaPepv9FnRIhSMfoErUhL64p0NX-KVgDAKxA1PEcvUroppYCOn6ATwkTdcLJC8XsMJuvZBY_DgN00ZR-iVaVza7HzKY_OV6P7ZfEmhrt5i4eihVit8fv11WW1_oCVN_jvFffOG-c3eBfDbMtb3N_jbZ6Ux2Mu7TlPIcf0Ej0b1Jjsq8N5in5efvlx8bW6_na1vji_rnTDmrlSg1Ad1UaB5aZhHeUtNdC3QlBD2cA04RwscCCaCSB13QKxtO_pwIymWtFT9Hnvu8v9ZI22fo5qlLvoJhXvZVBOPlS828pNuJVEcMKgKQbvDgYx_M42zXJySdtxVN6GnCQXnDWUPg6SltVAORTw4x7UMaQU7XDchoBcwpQlTLmEKUuYBX_z_w_-wfv0iv72oKuk1ThE5bVLR4wJQihfbPAe82rO0R71MmsZtUz6AxqYsws</recordid><startdate>19900501</startdate><enddate>19900501</enddate><creator>REEVE, J. 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M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Production of immunoreactive insulin-like growth factor-I (IGF-I) and IGF-I binding proteins by human lung tumours</atitle><jtitle>British journal of cancer</jtitle><addtitle>Br J Cancer</addtitle><date>1990-05-01</date><risdate>1990</risdate><volume>61</volume><issue>5</issue><spage>727</spage><epage>731</epage><pages>727-731</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>The production of insulin-like growth factor I (IGF-I) and IGF-I binding proteins (BPs) by human lung tumour cell lines in vitro has been examined and the levels of these substances in the serum of lung cancer patients investigated. While small cell lung cancer (SCLC) cell lines secreted both IGF-I and BPs, non-small cell lung cancer (NSCLC) cell lines secreted BPs only. 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| ispartof | British journal of cancer, 1990-05, Vol.61 (5), p.727-731 |
| issn | 0007-0920 1532-1827 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Nature Journals Online; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Biological and medical sciences Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Small Cell - metabolism Carrier Proteins - metabolism Humans Insulin-Like Growth Factor Binding Proteins Insulin-Like Growth Factor I - metabolism Lung Neoplasms - metabolism Medical sciences Pneumology Somatomedins - metabolism Tumor Cells, Cultured - metabolism Tumors of the respiratory system and mediastinum |
| title | Production of immunoreactive insulin-like growth factor-I (IGF-I) and IGF-I binding proteins by human lung tumours |
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