Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease
The messenger RNAs for the angiogenic acidic and basic fibroblast growth factors are expressed at a significantly higher level in samples of human benign neoplastic and hyperplastic tissue than in samples from breast cancers. However, approximately one in four malignant breast cancer samples contain...
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| Veröffentlicht in: | British journal of cancer 1994-04, Vol.69 (4), p.772-776 |
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| container_title | British journal of cancer |
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| creator | ANANDAPPA, S. Y WINSTANLEY, J. H. R LEINSTER, S GREEN, B RUDLAND, P. S BARRACLOUGH, R |
| description | The messenger RNAs for the angiogenic acidic and basic fibroblast growth factors are expressed at a significantly higher level in samples of human benign neoplastic and hyperplastic tissue than in samples from breast cancers. However, approximately one in four malignant breast cancer samples contain basic fibroblast growth factor mRNA at the same level as in the benign lesions when basic fibroblast growth factor mRNA levels are corrected with respect to levels of expression of glyceraldehyde-3-phosphate dehydrogenase mRNA. A similar proportion of human malignant breast cancer cell lines express a high level of basic fibroblast growth factor mRNA. The results suggest that some malignant breast cancers and their constitutive carcinoma cells express abundant levels of basic fibroblast growth factor mRNA. The resultant production of basic fibroblast growth factor by breast cancer cells within some tumours may contribute to their development. |
| doi_str_mv | 10.1038/bjc.1994.146 |
| format | Article |
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The results suggest that some malignant breast cancers and their constitutive carcinoma cells express abundant levels of basic fibroblast growth factor mRNA. The resultant production of basic fibroblast growth factor by breast cancer cells within some tumours may contribute to their development.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.1994.146</identifier><identifier>PMID: 7511406</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Blotting, Northern ; Breast Diseases - metabolism ; Breast Neoplasms - chemistry ; Breast Neoplasms - metabolism ; DNA Probes ; Female ; Fibroblast Growth Factor 1 - biosynthesis ; Fibroblast Growth Factor 2 - biosynthesis ; Glyceraldehyde-3-Phosphate Dehydrogenases - biosynthesis ; Gynecology. Andrology. 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Y</creatorcontrib><creatorcontrib>WINSTANLEY, J. H. R</creatorcontrib><creatorcontrib>LEINSTER, S</creatorcontrib><creatorcontrib>GREEN, B</creatorcontrib><creatorcontrib>RUDLAND, P. S</creatorcontrib><creatorcontrib>BARRACLOUGH, R</creatorcontrib><title>Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><description>The messenger RNAs for the angiogenic acidic and basic fibroblast growth factors are expressed at a significantly higher level in samples of human benign neoplastic and hyperplastic tissue than in samples from breast cancers. However, approximately one in four malignant breast cancer samples contain basic fibroblast growth factor mRNA at the same level as in the benign lesions when basic fibroblast growth factor mRNA levels are corrected with respect to levels of expression of glyceraldehyde-3-phosphate dehydrogenase mRNA. A similar proportion of human malignant breast cancer cell lines express a high level of basic fibroblast growth factor mRNA. The results suggest that some malignant breast cancers and their constitutive carcinoma cells express abundant levels of basic fibroblast growth factor mRNA. The resultant production of basic fibroblast growth factor by breast cancer cells within some tumours may contribute to their development.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Breast Diseases - metabolism</subject><subject>Breast Neoplasms - chemistry</subject><subject>Breast Neoplasms - metabolism</subject><subject>DNA Probes</subject><subject>Female</subject><subject>Fibroblast Growth Factor 1 - biosynthesis</subject><subject>Fibroblast Growth Factor 2 - biosynthesis</subject><subject>Glyceraldehyde-3-Phosphate Dehydrogenases - biosynthesis</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Poly A - analysis</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Neoplasm - analysis</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc9rFDEYhoModV29eRVyEE_O-mUyk0wuQln8BaUF0XNIMt9sU2aSNZlt7X_fDLssevoS3iffG3gIectgw4B3n-yd2zClmg1rxDOyYi2vK9bV8jlZAYCsQNXwkrzK-a5cFXTyglzIlrEGxIrobZz2JpnZ3yPFv_uEOfsYaBzo4G2KdjR5prsUH-ZbOhg3x0Snn9eXmfpALQa_C9SEnk5mLEcTZmoTLk96n8vE1-TFYMaMb05zTX5__fJr-726uvn2Y3t5VTnedKKybW8540NnZC84Og4NtDXIAWSnnFS9aJ1FrIEJEJ2SSgrhODbgnJWtk3xNPh_37g92wt5hmJMZ9T75yaRHHY3X_yfB3-pdvNdMia4r1Wvy4bQgxT8HzLOefHY4jiZgPGQtRcNAtHUBPx5Bl2LOCYdzCQO9CNFFiF6E6CKk4O_-_dgZPhko-ftTbrIz45BMcD6fsQaghVoVjB6xYOZDwnNeupaqpekJ_safow</recordid><startdate>19940401</startdate><enddate>19940401</enddate><creator>ANANDAPPA, S. 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Obstetrics</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Poly A - analysis</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Neoplasm - analysis</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ANANDAPPA, S. Y</creatorcontrib><creatorcontrib>WINSTANLEY, J. H. R</creatorcontrib><creatorcontrib>LEINSTER, S</creatorcontrib><creatorcontrib>GREEN, B</creatorcontrib><creatorcontrib>RUDLAND, P. 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S</au><au>BARRACLOUGH, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease</atitle><jtitle>British journal of cancer</jtitle><addtitle>Br J Cancer</addtitle><date>1994-04-01</date><risdate>1994</risdate><volume>69</volume><issue>4</issue><spage>772</spage><epage>776</epage><pages>772-776</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>The messenger RNAs for the angiogenic acidic and basic fibroblast growth factors are expressed at a significantly higher level in samples of human benign neoplastic and hyperplastic tissue than in samples from breast cancers. However, approximately one in four malignant breast cancer samples contain basic fibroblast growth factor mRNA at the same level as in the benign lesions when basic fibroblast growth factor mRNA levels are corrected with respect to levels of expression of glyceraldehyde-3-phosphate dehydrogenase mRNA. A similar proportion of human malignant breast cancer cell lines express a high level of basic fibroblast growth factor mRNA. The results suggest that some malignant breast cancers and their constitutive carcinoma cells express abundant levels of basic fibroblast growth factor mRNA. The resultant production of basic fibroblast growth factor by breast cancer cells within some tumours may contribute to their development.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>7511406</pmid><doi>10.1038/bjc.1994.146</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Nature; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Blotting, Northern Breast Diseases - metabolism Breast Neoplasms - chemistry Breast Neoplasms - metabolism DNA Probes Female Fibroblast Growth Factor 1 - biosynthesis Fibroblast Growth Factor 2 - biosynthesis Glyceraldehyde-3-Phosphate Dehydrogenases - biosynthesis Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Middle Aged Poly A - analysis RNA, Messenger - analysis RNA, Neoplasm - analysis Tumor Cells, Cultured Tumors |
| title | Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease |
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