Direct comparison of a radioiodinated intact chimeric anti-CEA Mab with its F(ab')2 fragment in nude mice bearing different human colon cancer xenografts

Tumour localisation and tumour to normal tissue ratios of a chimeric anti-carcinoembryonic antigen (CEA) monoclonal antibody (MAb), in intact form and as an F(ab')2 fragment labelled with 125I and 131I, were compared in groups of nude mice bearing four different colon cancer xenografts, T380, C...

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