Transforming growth factor-β 1 as a signal for induction of cell death by apoptosis
Cell death by apoptosis is a major determinant of growth of normal tissues and tumours. The present study aimed to elucidate signal factors involved in its regulation. Epithelial cells in control liver, during regression of cyproterone acetate induced liver hyperplasia, in liver (pre)neoplasia and i...
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| Veröffentlicht in: | British journal of cancer 1993-03, Vol.67 (3), p.531-536 |
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| container_title | British journal of cancer |
| container_volume | 67 |
| creator | Bursch, W Oberhammer, F Jirtle, RL Askari, M Sedivy, R Grasl-Kraupp, B Purchio, AF Schulte-Hermann, R |
| description | Cell death by apoptosis is a major determinant of growth of normal tissues and tumours. The present study aimed to elucidate signal factors involved in its regulation. Epithelial cells in control liver, during regression of cyproterone acetate induced liver hyperplasia, in liver (pre)neoplasia and in uterus undergoing apoptosis in vivo show immunostaining for transforming growth factor beta 1 (TGF-beta 1) as detected by anti-pre(266-278) TGF-beta 1 antibodies. Positive immunostaining is also seen in a few intact cells of hyperplastic, regressing liver apparently preparing for apoptosis, but is virtually not found in hepatocytes of normal or growing liver nor in cells undergoing death by necrosis. Recombinant latency associated protein (rLAP, dimer of the pro-region non-covalently associated with the mature region) complex and mature TGF-beta 1 induce apoptosis in isolated hepatocytes cultured in vitro. These findings suggest an involvement of TGF-beta 1 in the induction of apoptosis in certain epithelia in vivo. |
| doi_str_mv | 10.1038/bjc.1993.98 |
| format | Article |
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The present study aimed to elucidate signal factors involved in its regulation. Epithelial cells in control liver, during regression of cyproterone acetate induced liver hyperplasia, in liver (pre)neoplasia and in uterus undergoing apoptosis in vivo show immunostaining for transforming growth factor beta 1 (TGF-beta 1) as detected by anti-pre(266-278) TGF-beta 1 antibodies. Positive immunostaining is also seen in a few intact cells of hyperplastic, regressing liver apparently preparing for apoptosis, but is virtually not found in hepatocytes of normal or growing liver nor in cells undergoing death by necrosis. Recombinant latency associated protein (rLAP, dimer of the pro-region non-covalently associated with the mature region) complex and mature TGF-beta 1 induce apoptosis in isolated hepatocytes cultured in vitro. These findings suggest an involvement of TGF-beta 1 in the induction of apoptosis in certain epithelia in vivo.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.1993.98</identifier><identifier>PMID: 8439503</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Apoptosis - physiology ; Biomarkers - analysis ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cell Death - drug effects ; Cell Death - physiology ; Cyproterone Acetate ; Drug Resistance ; Epidemiology ; experimental-oncology ; Female ; Hyperplasia - chemically induced ; Hyperplasia - pathology ; Liver - chemistry ; Liver - drug effects ; Liver - pathology ; Molecular Medicine ; Necrosis ; Oncology ; Rats ; Transforming Growth Factor beta - analysis</subject><ispartof>British journal of cancer, 1993-03, Vol.67 (3), p.531-536</ispartof><rights>Cancer Research Campaign 1993</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-75786b804422184c2c7cb6c964ac642cf1313764052c027d9e54122ec8d9c72d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968248/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968248/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8439503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bursch, W</creatorcontrib><creatorcontrib>Oberhammer, F</creatorcontrib><creatorcontrib>Jirtle, RL</creatorcontrib><creatorcontrib>Askari, M</creatorcontrib><creatorcontrib>Sedivy, R</creatorcontrib><creatorcontrib>Grasl-Kraupp, B</creatorcontrib><creatorcontrib>Purchio, AF</creatorcontrib><creatorcontrib>Schulte-Hermann, R</creatorcontrib><title>Transforming growth factor-β 1 as a signal for induction of cell death by apoptosis</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Cell death by apoptosis is a major determinant of growth of normal tissues and tumours. The present study aimed to elucidate signal factors involved in its regulation. Epithelial cells in control liver, during regression of cyproterone acetate induced liver hyperplasia, in liver (pre)neoplasia and in uterus undergoing apoptosis in vivo show immunostaining for transforming growth factor beta 1 (TGF-beta 1) as detected by anti-pre(266-278) TGF-beta 1 antibodies. Positive immunostaining is also seen in a few intact cells of hyperplastic, regressing liver apparently preparing for apoptosis, but is virtually not found in hepatocytes of normal or growing liver nor in cells undergoing death by necrosis. Recombinant latency associated protein (rLAP, dimer of the pro-region non-covalently associated with the mature region) complex and mature TGF-beta 1 induce apoptosis in isolated hepatocytes cultured in vitro. These findings suggest an involvement of TGF-beta 1 in the induction of apoptosis in certain epithelia in vivo.</description><subject>Animals</subject><subject>Apoptosis - physiology</subject><subject>Biomarkers - analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cell Death - drug effects</subject><subject>Cell Death - physiology</subject><subject>Cyproterone Acetate</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>experimental-oncology</subject><subject>Female</subject><subject>Hyperplasia - chemically induced</subject><subject>Hyperplasia - pathology</subject><subject>Liver - chemistry</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Molecular Medicine</subject><subject>Necrosis</subject><subject>Oncology</subject><subject>Rats</subject><subject>Transforming Growth Factor beta - analysis</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkctqGzEYhUVpSJ20q64LWnWTjKvb6LIJBJMbGLJx10Kj0UxkxpIjzST4tfIgeabOYGNSyOpHnE_nl84B4CdGc4yo_FOt7RwrRedKfgEzXFJSYEnEVzBDCIkCKYK-gbOc1-NRISlOwalkVJWIzsBqlUzITUwbH1rYpvjaP8HG2D6m4v0NYmgyNDD7NpgOjhj0oR5s72OAsYHWdR2snRnvVDtotnHbx-zzd3DSmC67H4d5Dv7e3qwW98Xy8e5hcb0sLGVlX4hSSF5JxBghWDJLrLAVt4ozYzkjtsEUU8EZKolFRNTKlQwT4qyslRWkpufgau-7HaqNq60LfTKd3ia_MWmno_H6fyX4J93GF40Vl4TJ0eD3wSDF58HlXm98nj5lgotD1qLkiAs-gRd70KaYc3LNcQlGeipBjyXoqQStJvrXx3cd2UPqo3651_OohNYlvY5DGhPOn9r9A9Jrkis</recordid><startdate>19930301</startdate><enddate>19930301</enddate><creator>Bursch, W</creator><creator>Oberhammer, F</creator><creator>Jirtle, RL</creator><creator>Askari, M</creator><creator>Sedivy, R</creator><creator>Grasl-Kraupp, B</creator><creator>Purchio, AF</creator><creator>Schulte-Hermann, R</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19930301</creationdate><title>Transforming growth factor-β 1 as a signal for induction of cell death by apoptosis</title><author>Bursch, W ; Oberhammer, F ; Jirtle, RL ; Askari, M ; Sedivy, R ; Grasl-Kraupp, B ; Purchio, AF ; Schulte-Hermann, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-75786b804422184c2c7cb6c964ac642cf1313764052c027d9e54122ec8d9c72d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Apoptosis - physiology</topic><topic>Biomarkers - analysis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Cell Death - drug effects</topic><topic>Cell Death - physiology</topic><topic>Cyproterone Acetate</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>experimental-oncology</topic><topic>Female</topic><topic>Hyperplasia - chemically induced</topic><topic>Hyperplasia - pathology</topic><topic>Liver - chemistry</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Molecular Medicine</topic><topic>Necrosis</topic><topic>Oncology</topic><topic>Rats</topic><topic>Transforming Growth Factor beta - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bursch, W</creatorcontrib><creatorcontrib>Oberhammer, F</creatorcontrib><creatorcontrib>Jirtle, RL</creatorcontrib><creatorcontrib>Askari, M</creatorcontrib><creatorcontrib>Sedivy, R</creatorcontrib><creatorcontrib>Grasl-Kraupp, B</creatorcontrib><creatorcontrib>Purchio, AF</creatorcontrib><creatorcontrib>Schulte-Hermann, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bursch, W</au><au>Oberhammer, F</au><au>Jirtle, RL</au><au>Askari, M</au><au>Sedivy, R</au><au>Grasl-Kraupp, B</au><au>Purchio, AF</au><au>Schulte-Hermann, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transforming growth factor-β 1 as a signal for induction of cell death by apoptosis</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>1993-03-01</date><risdate>1993</risdate><volume>67</volume><issue>3</issue><spage>531</spage><epage>536</epage><pages>531-536</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><abstract>Cell death by apoptosis is a major determinant of growth of normal tissues and tumours. The present study aimed to elucidate signal factors involved in its regulation. Epithelial cells in control liver, during regression of cyproterone acetate induced liver hyperplasia, in liver (pre)neoplasia and in uterus undergoing apoptosis in vivo show immunostaining for transforming growth factor beta 1 (TGF-beta 1) as detected by anti-pre(266-278) TGF-beta 1 antibodies. Positive immunostaining is also seen in a few intact cells of hyperplastic, regressing liver apparently preparing for apoptosis, but is virtually not found in hepatocytes of normal or growing liver nor in cells undergoing death by necrosis. Recombinant latency associated protein (rLAP, dimer of the pro-region non-covalently associated with the mature region) complex and mature TGF-beta 1 induce apoptosis in isolated hepatocytes cultured in vitro. These findings suggest an involvement of TGF-beta 1 in the induction of apoptosis in certain epithelia in vivo.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8439503</pmid><doi>10.1038/bjc.1993.98</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Apoptosis - physiology Biomarkers - analysis Biomedical and Life Sciences Biomedicine Cancer Research Cell Death - drug effects Cell Death - physiology Cyproterone Acetate Drug Resistance Epidemiology experimental-oncology Female Hyperplasia - chemically induced Hyperplasia - pathology Liver - chemistry Liver - drug effects Liver - pathology Molecular Medicine Necrosis Oncology Rats Transforming Growth Factor beta - analysis |
| title | Transforming growth factor-β 1 as a signal for induction of cell death by apoptosis |
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