The human EGF receptor as a target for cancer therapy: six new rat mAbs against the receptor on the breast carcinoma MDA-MB 468

Using the breast carcinoma cell line MDA-MB 468 as immunogen, we have produced six new rat monoclonal antibodies (mAbs) against the human EGF receptor (EGFR) and are investigating their use for diagnostic and therapeutic applications in cancer patients whose tumours overexpress these receptors. The...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of cancer 1993-02, Vol.67 (2), p.247-253
Hauptverfasser:	Modjtahedi, H, Styles, JM, Dean, CJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - pharmacology Antineoplastic agents Biological and medical sciences Biomedical and Life Sciences Biomedicine Breast Neoplasms - immunology Breast Neoplasms - metabolism Breast Neoplasms - ultrastructure Cancer Research Cell Division - drug effects Cross Reactions Drug Resistance Epidemiology Epidermal Growth Factor - pharmacology ErbB Receptors - immunology ErbB Receptors - metabolism ErbB Receptors - physiology experimental-oncology Female Fibroblasts - cytology Fibroblasts - drug effects Humans Hybridomas - immunology Hybridomas - metabolism Immunoglobulin G - pharmacology Immunotherapy Medical sciences Mice Molecular Medicine Oncology Pharmacology. Drug treatments Proto-Oncogene Proteins - genetics Rats Rats, Inbred Strains Rats, Nude Receptor, ErbB-2 Transforming Growth Factor alpha - pharmacology Tumor Cells, Cultured Vulvar Neoplasms - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!