Phospholipase D Activity Is Regulated by Product Segregation and the Structure Formation of Phosphatidic Acid within Model Membranes

Phospholipase D from Streptomyces chromofuscus (scPLD) hydrolyzes phosphatidylcholines (PC) to produce choline and phosphatidic acid (PA), a lipid messenger molecule within biological membranes. To scrutinize the influence of membrane structure on scPLD activity, three different substrate-containing...

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Veröffentlicht in:	Biophysical journal 2007-10, Vol.93 (7), p.2373-2383
Hauptverfasser:	Wagner, Kerstin, Brezesinski, Gerald
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Biophysics Biophysics - methods Calcium - chemistry Cell Membrane - metabolism Cellular biology Enzyme Inhibitors - pharmacology Enzymes Gene Expression Regulation, Enzymologic Hydrolysis Lipids Lipids - chemistry Membranes Microscopy, Atomic Force Models, Biological Molecules Monolayers Palmitates - chemistry Phosphatidic Acids - chemistry Phospholipase Phospholipase D - biosynthesis Phospholipase D - chemistry Polycarbonates Segregations Streptomyces - metabolism Substrate Specificity Surface pressure X-Ray Diffraction
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