Persistent Tissue Kinetics and Redistribution of Nanoparticles, Quantum Dot 705, in Mice: ICP-MS Quantitative Assessment
Background: Quantum dots (QDs) are autofluorescent semiconductor nanocrystals that can be used for in vivo biomedical imaging. However, we know little about their in vivo disposition and health consequences. Objectives: We assessed the tissue disposition and pharmacokinetics of QD705 in mice. Method...
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| Veröffentlicht in: | Environmental health perspectives 2007-09, Vol.115 (9), p.1339-1343 |
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| creator | Raymond S. H. Yang Chang, Louis W. Jui-Pin Wu Ming-Hsien Tsai Hsiu-Jen Wang Yu-Chun Kuo Teng-Kuang Yeh Chung Shi Yang Pinpin Lin |
| description | Background: Quantum dots (QDs) are autofluorescent semiconductor nanocrystals that can be used for in vivo biomedical imaging. However, we know little about their in vivo disposition and health consequences. Objectives: We assessed the tissue disposition and pharmacokinetics of QD705 in mice. Methods: We determined quantitatively the blood and tissue kinetics of QD705 in mice after single intravenous (iv) injection at the dose of 40 pmol for up to 28 days. Inductively coupled plasmamass spectrometry (ICP-MS) measurement of cadmium was the primary method of quantification of QD705. Fluorescence light microscopy revealed the localization of QD705 in tissues. Results: Plasma half-life of QD705 in mice was short (18.5 hr), but ICP-MS analyses revealed QD705 persisted and even continued to increase in the spleen, liver, and kidney 28 days after an iv dose. Considerable time-dependent redistribution from body mass to liver and kidney was apparent between 1 and 28 days postdosing. The recoveries at both time points were near 100%; all QD705s reside in the body. Neither fecal nor urinary excretion of QD705 was detected appreciably in 28 days postdosing. Fluorescence microscopy demonstrated deposition of QD705 in the liver, spleen, and kidneys. Conclusion: Judging from the continued increase in the liver (29-42% of the administered dose), kidney (1.5-9.2%), and spleen (4.8-5.2%) between 1 and 28 days without any appreciable excretion, QD705 has a very long half-life, potentially weeks or even months, in the body and its health consequences deserve serious consideration. |
| doi_str_mv | 10.1289/ehp.10290 |
| format | Article |
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H. Yang ; Chang, Louis W. ; Jui-Pin Wu ; Ming-Hsien Tsai ; Hsiu-Jen Wang ; Yu-Chun Kuo ; Teng-Kuang Yeh ; Chung Shi Yang ; Pinpin Lin</creator><creatorcontrib>Raymond S. H. Yang ; Chang, Louis W. ; Jui-Pin Wu ; Ming-Hsien Tsai ; Hsiu-Jen Wang ; Yu-Chun Kuo ; Teng-Kuang Yeh ; Chung Shi Yang ; Pinpin Lin</creatorcontrib><description>Background: Quantum dots (QDs) are autofluorescent semiconductor nanocrystals that can be used for in vivo biomedical imaging. However, we know little about their in vivo disposition and health consequences. Objectives: We assessed the tissue disposition and pharmacokinetics of QD705 in mice. Methods: We determined quantitatively the blood and tissue kinetics of QD705 in mice after single intravenous (iv) injection at the dose of 40 pmol for up to 28 days. Inductively coupled plasmamass spectrometry (ICP-MS) measurement of cadmium was the primary method of quantification of QD705. Fluorescence light microscopy revealed the localization of QD705 in tissues. Results: Plasma half-life of QD705 in mice was short (18.5 hr), but ICP-MS analyses revealed QD705 persisted and even continued to increase in the spleen, liver, and kidney 28 days after an iv dose. Considerable time-dependent redistribution from body mass to liver and kidney was apparent between 1 and 28 days postdosing. The recoveries at both time points were near 100%; all QD705s reside in the body. Neither fecal nor urinary excretion of QD705 was detected appreciably in 28 days postdosing. Fluorescence microscopy demonstrated deposition of QD705 in the liver, spleen, and kidneys. Conclusion: Judging from the continued increase in the liver (29-42% of the administered dose), kidney (1.5-9.2%), and spleen (4.8-5.2%) between 1 and 28 days without any appreciable excretion, QD705 has a very long half-life, potentially weeks or even months, in the body and its health consequences deserve serious consideration.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.10290</identifier><identifier>PMID: 17805425</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</publisher><subject>Animals ; Blood plasma ; Fluorescence ; Health aspects ; Imaging ; Kidneys ; Kinetics ; Liver ; Male ; Mice ; Mice, Inbred ICR ; Nanocrystals ; Nanoparticles ; Pharmacokinetics ; Quantum Dots ; Rats as laboratory animals ; Spleen ; Tissue Distribution</subject><ispartof>Environmental health perspectives, 2007-09, Vol.115 (9), p.1339-1343</ispartof><rights>COPYRIGHT 2007 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences Sep 2007</rights><rights>2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-b7692fb4b8d18780d64a787a1db5a05bd493a3cd6d811ef6f1a10c1b9074ce7d3</citedby><cites>FETCH-LOGICAL-c725t-b7692fb4b8d18780d64a787a1db5a05bd493a3cd6d811ef6f1a10c1b9074ce7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4626898$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4626898$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,860,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17805425$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raymond S. H. Yang</creatorcontrib><creatorcontrib>Chang, Louis W.</creatorcontrib><creatorcontrib>Jui-Pin Wu</creatorcontrib><creatorcontrib>Ming-Hsien Tsai</creatorcontrib><creatorcontrib>Hsiu-Jen Wang</creatorcontrib><creatorcontrib>Yu-Chun Kuo</creatorcontrib><creatorcontrib>Teng-Kuang Yeh</creatorcontrib><creatorcontrib>Chung Shi Yang</creatorcontrib><creatorcontrib>Pinpin Lin</creatorcontrib><title>Persistent Tissue Kinetics and Redistribution of Nanoparticles, Quantum Dot 705, in Mice: ICP-MS Quantitative Assessment</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Background: Quantum dots (QDs) are autofluorescent semiconductor nanocrystals that can be used for in vivo biomedical imaging. However, we know little about their in vivo disposition and health consequences. Objectives: We assessed the tissue disposition and pharmacokinetics of QD705 in mice. Methods: We determined quantitatively the blood and tissue kinetics of QD705 in mice after single intravenous (iv) injection at the dose of 40 pmol for up to 28 days. Inductively coupled plasmamass spectrometry (ICP-MS) measurement of cadmium was the primary method of quantification of QD705. Fluorescence light microscopy revealed the localization of QD705 in tissues. Results: Plasma half-life of QD705 in mice was short (18.5 hr), but ICP-MS analyses revealed QD705 persisted and even continued to increase in the spleen, liver, and kidney 28 days after an iv dose. Considerable time-dependent redistribution from body mass to liver and kidney was apparent between 1 and 28 days postdosing. The recoveries at both time points were near 100%; all QD705s reside in the body. Neither fecal nor urinary excretion of QD705 was detected appreciably in 28 days postdosing. Fluorescence microscopy demonstrated deposition of QD705 in the liver, spleen, and kidneys. Conclusion: Judging from the continued increase in the liver (29-42% of the administered dose), kidney (1.5-9.2%), and spleen (4.8-5.2%) between 1 and 28 days without any appreciable excretion, QD705 has a very long half-life, potentially weeks or even months, in the body and its health consequences deserve serious consideration.</description><subject>Animals</subject><subject>Blood plasma</subject><subject>Fluorescence</subject><subject>Health aspects</subject><subject>Imaging</subject><subject>Kidneys</subject><subject>Kinetics</subject><subject>Liver</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Nanocrystals</subject><subject>Nanoparticles</subject><subject>Pharmacokinetics</subject><subject>Quantum Dots</subject><subject>Rats as laboratory animals</subject><subject>Spleen</subject><subject>Tissue Distribution</subject><issn>0091-6765</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN081v0zAUAPAIgdgYHLgjZHGYhLQU23EcewekqnxVbGxsg6vlJC-tq8QusTON_x53rcaKKg35EMnv52c7fi9JXhI8IlTIdzBfjgimEj9K9kme01RKyh4n-xhLkvKC53vJM-8XGGMiOH-a7JFC4JzRfD-5OYfeGx_ABnRlvB8AfTUWgqk80rZGF1DHaG_KIRhnkWvQN23dUvdRtOCP0PdB2zB06IMLqMD5ETIWnZoKjtF0cp6eXq6BCTqYa0Bj78H7Lu72PHnS6NbDi833IPnx6ePV5Et6cvZ5OhmfpFVB85CWBZe0KVkpaiLiqWvOdCEKTeoy1zgvayYznVU1rwUh0PCGaIIrUkpcsAqKOjtI3q_zLoeyg7qKW_e6VcvedLr_rZw2ajtizVzN3LUikjMh8pjgcJOgd78G8EF1xlfQttqCG7zigrIsK-iDkGKGGZfsQUiYoBlmq4xv_oELN_Q2_i5FKeWMcIEjStdopltQxjYuXqOagYV4G2ehMXF6TApMYmnIlR_t8HHU0Jlq54K3WwuiCXATZnrwXk0vL_7fnv3ctof37Bx0G-betbeF5ncmrXrnfQ_N3esRrFYNoGIDqNsGiPb1_ef-KzcVH8GrNVj44Pq7OOOUCymyP401Bxc</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Raymond S. 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Yang</creatorcontrib><creatorcontrib>Chang, Louis W.</creatorcontrib><creatorcontrib>Jui-Pin Wu</creatorcontrib><creatorcontrib>Ming-Hsien Tsai</creatorcontrib><creatorcontrib>Hsiu-Jen Wang</creatorcontrib><creatorcontrib>Yu-Chun Kuo</creatorcontrib><creatorcontrib>Teng-Kuang Yeh</creatorcontrib><creatorcontrib>Chung Shi Yang</creatorcontrib><creatorcontrib>Pinpin Lin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Engineering Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raymond S. H. Yang</au><au>Chang, Louis W.</au><au>Jui-Pin Wu</au><au>Ming-Hsien Tsai</au><au>Hsiu-Jen Wang</au><au>Yu-Chun Kuo</au><au>Teng-Kuang Yeh</au><au>Chung Shi Yang</au><au>Pinpin Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistent Tissue Kinetics and Redistribution of Nanoparticles, Quantum Dot 705, in Mice: ICP-MS Quantitative Assessment</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>115</volume><issue>9</issue><spage>1339</spage><epage>1343</epage><pages>1339-1343</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>Background: Quantum dots (QDs) are autofluorescent semiconductor nanocrystals that can be used for in vivo biomedical imaging. However, we know little about their in vivo disposition and health consequences. Objectives: We assessed the tissue disposition and pharmacokinetics of QD705 in mice. Methods: We determined quantitatively the blood and tissue kinetics of QD705 in mice after single intravenous (iv) injection at the dose of 40 pmol for up to 28 days. Inductively coupled plasmamass spectrometry (ICP-MS) measurement of cadmium was the primary method of quantification of QD705. Fluorescence light microscopy revealed the localization of QD705 in tissues. Results: Plasma half-life of QD705 in mice was short (18.5 hr), but ICP-MS analyses revealed QD705 persisted and even continued to increase in the spleen, liver, and kidney 28 days after an iv dose. Considerable time-dependent redistribution from body mass to liver and kidney was apparent between 1 and 28 days postdosing. The recoveries at both time points were near 100%; all QD705s reside in the body. Neither fecal nor urinary excretion of QD705 was detected appreciably in 28 days postdosing. Fluorescence microscopy demonstrated deposition of QD705 in the liver, spleen, and kidneys. Conclusion: Judging from the continued increase in the liver (29-42% of the administered dose), kidney (1.5-9.2%), and spleen (4.8-5.2%) between 1 and 28 days without any appreciable excretion, QD705 has a very long half-life, potentially weeks or even months, in the body and its health consequences deserve serious consideration.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>17805425</pmid><doi>10.1289/ehp.10290</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Blood plasma Fluorescence Health aspects Imaging Kidneys Kinetics Liver Male Mice Mice, Inbred ICR Nanocrystals Nanoparticles Pharmacokinetics Quantum Dots Rats as laboratory animals Spleen Tissue Distribution |
| title | Persistent Tissue Kinetics and Redistribution of Nanoparticles, Quantum Dot 705, in Mice: ICP-MS Quantitative Assessment |
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