Mechanism of p38 MAP kinase activation in vivo

The p38 mitogen-activated protein kinase (MAPK) is activated in vitro by three different protein kinases: MKK3, MKK4, and MKK6. To examine the relative roles of these protein kinases in the mechanism of p38 MAP kinase activation in vivo, we examined the effect of disruption of the murine Mkk3, Mkk4,...

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Veröffentlicht in:	Genes & development 2003-08, Vol.17 (16), p.1969-1978
Hauptverfasser:	Brancho, Deborah, Tanaka, Nobuyuki, Jaeschke, Anja, Ventura, Juan-Jose, Kelkar, Nyaya, Tanaka, Yoshinori, Kyuuma, Masanao, Takeshita, Toshikazu, Flavell, Richard A, Davis, Roger J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Enzyme Activation - drug effects Enzyme Activation - genetics Enzyme Activation - radiation effects Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - radiation effects Gene Expression Regulation - drug effects Gene Expression Regulation - radiation effects Male MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - radiation effects Mice Mice, Knockout Mice, Nude Mitogen-Activated Protein Kinase Kinases - deficiency Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinases - drug effects Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinases - radiation effects Mutation p38 Mitogen-Activated Protein Kinases Protein Isoforms - drug effects Protein Isoforms - metabolism Protein Isoforms - radiation effects Research Papers Trans-Activators - metabolism Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology Ultraviolet Rays - adverse effects
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