The Permeability Enhancing Mechanism of DMSO in Ceramide Bilayers Simulated by Molecular Dynamics

The lipids of the topmost layer of the skin, the stratum corneum, represent the primary barrier to molecules penetrating the skin. One approach to overcoming this barrier for the purpose of delivery of active molecules into or via the skin is to employ chemical permeability enhancers, such as dimeth...

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Veröffentlicht in:Biophysical journal 2007-09, Vol.93 (6), p.2056-2068
Hauptverfasser: Notman, Rebecca, den Otter, Wouter K., Noro, Massimo G., Briels, W.J., Anwar, Jamshed
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Sprache:eng
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