Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape
Based on early studies, it was hypothesized that expression of Fas ligand (FasL) by tumor cells enabled them to counterattack the immune system, and that transplant rejection could be prevented by expressing FasL on transplanted organs. More recent studies have indicated that the notion of FasL as a...
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| Veröffentlicht in: | Nature medicine 2000-05, Vol.6 (5), p.493-495 |
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| creator | Restifo, Nicholas P. |
| description | Based on early studies, it was hypothesized that expression of Fas ligand (FasL) by tumor cells enabled them to counterattack the immune system, and that transplant rejection could be prevented by expressing FasL on transplanted organs. More recent studies have indicated that the notion of FasL as a mediator of immune privilege needed to be reconsidered, and taught a valuable lesson about making broad conclusions based on small amounts of data. |
| doi_str_mv | 10.1038/74955 |
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| ispartof | Nature medicine, 2000-05, Vol.6 (5), p.493-495 |
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| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Biomedical and Life Sciences Biomedicine Cancer cells Cancer Research Cell Death commentary Cytokines Experiments Fas Ligand Protein Genetic aspects Health aspects Hypotheses Immune system Immune Tolerance Immunity, Cellular Immunology Infectious Diseases Ligands Lymphocytes Melanoma Membrane Glycoproteins - immunology Membrane proteins Metabolic Diseases Models, Immunological Molecular Medicine Neurosciences Physiological aspects Transgenic animals Transplantation Immunology - immunology Transplants & implants Tumor Escape - immunology Tumors |
| title | Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape |
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