Polypoidal choroidal vasculopathy appearing as classic choroidal neovascularisation on fluorescein angiography
Aims:To study the visual prognosis and ocular characteristics of eyes with polypoidal choroidal vasculopathy (PCV) that appear to have classic choroidal neovascularisation (CNV) on fluorescein angiography (FA).Methods:The authors reviewed retrospectively 38 eyes with PCV that appear to have classic...
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| Veröffentlicht in: | British journal of ophthalmology 2007-09, Vol.91 (9), p.1152-1159 |
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| creator | Tamura, Hiroshi Tsujikawa, Akitaka Otani, Atsushi Gotoh, Norimoto Sasahara, Manabu Kameda, Takanori Iwama, Daisuke Yodoi, Yuko Mandai, Michiko Yoshimura, Nagahisa |
| description | Aims:To study the visual prognosis and ocular characteristics of eyes with polypoidal choroidal vasculopathy (PCV) that appear to have classic choroidal neovascularisation (CNV) on fluorescein angiography (FA).Methods:The authors reviewed retrospectively 38 eyes with PCV that appear to have classic CNV on FA. Lesions were examined with indocyanine green angiography, FA and optical coherence tomography (OCT).Results:In all cases OCT showed subretinal material with moderate reflectivity that corresponded in location to classic CNV. At the final visit, the subretinal material resolved completely in 14 eyes (36.8%, resolved group), but resolved only incompletely in 24 eyes (63.2%, persisted group) after photodynamic therapy (PDT). Mean (standard deviation) visual acuity in the resolved group (0.35 (0.41) in log MAR) was significantly better than that in the persisted group (0.84 (0.24)) at the final visit (p |
| doi_str_mv | 10.1136/bjo.2006.112318 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1954949</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68183716</sourcerecordid><originalsourceid>FETCH-LOGICAL-b558t-dd61346cdf7b16f88ae0cb850a26c5a291fcc382c25fd4d1dfdb6c09705f28fb3</originalsourceid><addsrcrecordid>eNqFkUFr3DAQhUVpabZpz70VQ6GHghONbEvypVA2TVIIaQ9prmIsS7vaei1HskP330eLlzTtJSCQhvn0Zh6PkPdATwAKftps_AmjlKeKFSBfkAWUXOaMivolWVBKRQ7A4Yi8iXGTSsZBvCZHIAoooZQL0v_03W7wrsUu02sf5tc9Rj11fsBxvctwGAwG168yjJnuMEann7C98TOemIij832Wju0mH0zUxvUZ9ivnVwGH9e4teWWxi-bd4T4mv86_3Swv86sfF9-XX6_ypqrkmLcth6LkurWiAW6lREN1IyuKjOsKWQ1W60IyzSrbli20tm24prWglWXSNsUx-TLrDlOzNa02_RiwU0NwWww75dGpfzu9W6uVv1dQV2Vd1kng00Eg-LvJxFFtXXLTdZj8TlFxCbIQwBP48T9w46fQJ3MKhJA1qwrYy53OlA4-xmDs4ypA1T5JlZJU-yTVnGT68eGpg7_8IboE5DPg4mj-PPYx_FZcFKJS17dLdS7h7Oz25lLtV_g888128-z0B7UBunw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1778925319</pqid></control><display><type>article</type><title>Polypoidal choroidal vasculopathy appearing as classic choroidal neovascularisation on fluorescein angiography</title><source>Electronic Journals Library</source><source>PubMed (Medline)</source><source>BMJ Journals Online Archive</source><source>MEDLINE</source><creator>Tamura, Hiroshi ; Tsujikawa, Akitaka ; Otani, Atsushi ; Gotoh, Norimoto ; Sasahara, Manabu ; Kameda, Takanori ; Iwama, Daisuke ; Yodoi, Yuko ; Mandai, Michiko ; Yoshimura, Nagahisa</creator><creatorcontrib>Tamura, Hiroshi ; Tsujikawa, Akitaka ; Otani, Atsushi ; Gotoh, Norimoto ; Sasahara, Manabu ; Kameda, Takanori ; Iwama, Daisuke ; Yodoi, Yuko ; Mandai, Michiko ; Yoshimura, Nagahisa</creatorcontrib><description>Aims:To study the visual prognosis and ocular characteristics of eyes with polypoidal choroidal vasculopathy (PCV) that appear to have classic choroidal neovascularisation (CNV) on fluorescein angiography (FA).Methods:The authors reviewed retrospectively 38 eyes with PCV that appear to have classic CNV on FA. Lesions were examined with indocyanine green angiography, FA and optical coherence tomography (OCT).Results:In all cases OCT showed subretinal material with moderate reflectivity that corresponded in location to classic CNV. At the final visit, the subretinal material resolved completely in 14 eyes (36.8%, resolved group), but resolved only incompletely in 24 eyes (63.2%, persisted group) after photodynamic therapy (PDT). Mean (standard deviation) visual acuity in the resolved group (0.35 (0.41) in log MAR) was significantly better than that in the persisted group (0.84 (0.24)) at the final visit (p<0.001). The subretinal material seen before treatment was more frequently seen in subfovea in the persisted group (87.5% vs 42.9%, p = 0.007). Also, this material was located adjacent to polypoidal lesions more often in the resolved group (92.9% vs 58.3%, p = 0.030).Conclusions:Eyes with PCV sometimes show classic CNV with subretinal material apparent on OCT, and PCV is thus attributed to type 2 CNV or to pure fibrinous tissue without CNV. Visual prognosis in eyes with type 2 CNV is poor, and although it is difficult to discriminate type 2 CNV from pure fibrin deposition before treatment, type 2 CNV is seen more often in the subfovea and is typically separate from the polypoidal lesions.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.2006.112318</identifier><identifier>PMID: 17314148</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Aged ; Aged, 80 and over ; Choroid - blood supply ; Choroidal Neovascularization - diagnosis ; Choroidal Neovascularization - physiopathology ; Clinical Science - Extended Report ; Diagnosis, Differential ; Female ; Fluorescein Angiography ; Humans ; Lasers ; Macular degeneration ; Male ; Medical imaging ; Middle Aged ; Myopia ; Peripheral Vascular Diseases - diagnosis ; Peripheral Vascular Diseases - drug therapy ; Peripheral Vascular Diseases - physiopathology ; Photochemotherapy ; Prognosis ; Retrospective Studies ; Tomography, Optical Coherence ; Visual Acuity</subject><ispartof>British journal of ophthalmology, 2007-09, Vol.91 (9), p.1152-1159</ispartof><rights>2007 BMJ Publishing Group</rights><rights>Copyright: 2007 2007 BMJ Publishing Group</rights><rights>Copyright © 2007 BMJ Publishing Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b558t-dd61346cdf7b16f88ae0cb850a26c5a291fcc382c25fd4d1dfdb6c09705f28fb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bjo.bmj.com/content/91/9/1152.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://bjo.bmj.com/content/91/9/1152.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,314,723,776,780,881,3183,23550,27901,27902,53766,53768,77342,77373</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17314148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tamura, Hiroshi</creatorcontrib><creatorcontrib>Tsujikawa, Akitaka</creatorcontrib><creatorcontrib>Otani, Atsushi</creatorcontrib><creatorcontrib>Gotoh, Norimoto</creatorcontrib><creatorcontrib>Sasahara, Manabu</creatorcontrib><creatorcontrib>Kameda, Takanori</creatorcontrib><creatorcontrib>Iwama, Daisuke</creatorcontrib><creatorcontrib>Yodoi, Yuko</creatorcontrib><creatorcontrib>Mandai, Michiko</creatorcontrib><creatorcontrib>Yoshimura, Nagahisa</creatorcontrib><title>Polypoidal choroidal vasculopathy appearing as classic choroidal neovascularisation on fluorescein angiography</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>Aims:To study the visual prognosis and ocular characteristics of eyes with polypoidal choroidal vasculopathy (PCV) that appear to have classic choroidal neovascularisation (CNV) on fluorescein angiography (FA).Methods:The authors reviewed retrospectively 38 eyes with PCV that appear to have classic CNV on FA. Lesions were examined with indocyanine green angiography, FA and optical coherence tomography (OCT).Results:In all cases OCT showed subretinal material with moderate reflectivity that corresponded in location to classic CNV. At the final visit, the subretinal material resolved completely in 14 eyes (36.8%, resolved group), but resolved only incompletely in 24 eyes (63.2%, persisted group) after photodynamic therapy (PDT). Mean (standard deviation) visual acuity in the resolved group (0.35 (0.41) in log MAR) was significantly better than that in the persisted group (0.84 (0.24)) at the final visit (p<0.001). The subretinal material seen before treatment was more frequently seen in subfovea in the persisted group (87.5% vs 42.9%, p = 0.007). Also, this material was located adjacent to polypoidal lesions more often in the resolved group (92.9% vs 58.3%, p = 0.030).Conclusions:Eyes with PCV sometimes show classic CNV with subretinal material apparent on OCT, and PCV is thus attributed to type 2 CNV or to pure fibrinous tissue without CNV. Visual prognosis in eyes with type 2 CNV is poor, and although it is difficult to discriminate type 2 CNV from pure fibrin deposition before treatment, type 2 CNV is seen more often in the subfovea and is typically separate from the polypoidal lesions.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Choroid - blood supply</subject><subject>Choroidal Neovascularization - diagnosis</subject><subject>Choroidal Neovascularization - physiopathology</subject><subject>Clinical Science - Extended Report</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Humans</subject><subject>Lasers</subject><subject>Macular degeneration</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Myopia</subject><subject>Peripheral Vascular Diseases - diagnosis</subject><subject>Peripheral Vascular Diseases - drug therapy</subject><subject>Peripheral Vascular Diseases - physiopathology</subject><subject>Photochemotherapy</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Tomography, Optical Coherence</subject><subject>Visual Acuity</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUFr3DAQhUVpabZpz70VQ6GHghONbEvypVA2TVIIaQ9prmIsS7vaei1HskP330eLlzTtJSCQhvn0Zh6PkPdATwAKftps_AmjlKeKFSBfkAWUXOaMivolWVBKRQ7A4Yi8iXGTSsZBvCZHIAoooZQL0v_03W7wrsUu02sf5tc9Rj11fsBxvctwGAwG168yjJnuMEann7C98TOemIij832Wju0mH0zUxvUZ9ivnVwGH9e4teWWxi-bd4T4mv86_3Swv86sfF9-XX6_ypqrkmLcth6LkurWiAW6lREN1IyuKjOsKWQ1W60IyzSrbli20tm24prWglWXSNsUx-TLrDlOzNa02_RiwU0NwWww75dGpfzu9W6uVv1dQV2Vd1kng00Eg-LvJxFFtXXLTdZj8TlFxCbIQwBP48T9w46fQJ3MKhJA1qwrYy53OlA4-xmDs4ypA1T5JlZJU-yTVnGT68eGpg7_8IboE5DPg4mj-PPYx_FZcFKJS17dLdS7h7Oz25lLtV_g888128-z0B7UBunw</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Tamura, Hiroshi</creator><creator>Tsujikawa, Akitaka</creator><creator>Otani, Atsushi</creator><creator>Gotoh, Norimoto</creator><creator>Sasahara, Manabu</creator><creator>Kameda, Takanori</creator><creator>Iwama, Daisuke</creator><creator>Yodoi, Yuko</creator><creator>Mandai, Michiko</creator><creator>Yoshimura, Nagahisa</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070901</creationdate><title>Polypoidal choroidal vasculopathy appearing as classic choroidal neovascularisation on fluorescein angiography</title><author>Tamura, Hiroshi ; Tsujikawa, Akitaka ; Otani, Atsushi ; Gotoh, Norimoto ; Sasahara, Manabu ; Kameda, Takanori ; Iwama, Daisuke ; Yodoi, Yuko ; Mandai, Michiko ; Yoshimura, Nagahisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b558t-dd61346cdf7b16f88ae0cb850a26c5a291fcc382c25fd4d1dfdb6c09705f28fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Choroid - blood supply</topic><topic>Choroidal Neovascularization - diagnosis</topic><topic>Choroidal Neovascularization - physiopathology</topic><topic>Clinical Science - Extended Report</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Humans</topic><topic>Lasers</topic><topic>Macular degeneration</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Myopia</topic><topic>Peripheral Vascular Diseases - diagnosis</topic><topic>Peripheral Vascular Diseases - drug therapy</topic><topic>Peripheral Vascular Diseases - physiopathology</topic><topic>Photochemotherapy</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Tomography, Optical Coherence</topic><topic>Visual Acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tamura, Hiroshi</creatorcontrib><creatorcontrib>Tsujikawa, Akitaka</creatorcontrib><creatorcontrib>Otani, Atsushi</creatorcontrib><creatorcontrib>Gotoh, Norimoto</creatorcontrib><creatorcontrib>Sasahara, Manabu</creatorcontrib><creatorcontrib>Kameda, Takanori</creatorcontrib><creatorcontrib>Iwama, Daisuke</creatorcontrib><creatorcontrib>Yodoi, Yuko</creatorcontrib><creatorcontrib>Mandai, Michiko</creatorcontrib><creatorcontrib>Yoshimura, Nagahisa</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tamura, Hiroshi</au><au>Tsujikawa, Akitaka</au><au>Otani, Atsushi</au><au>Gotoh, Norimoto</au><au>Sasahara, Manabu</au><au>Kameda, Takanori</au><au>Iwama, Daisuke</au><au>Yodoi, Yuko</au><au>Mandai, Michiko</au><au>Yoshimura, Nagahisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polypoidal choroidal vasculopathy appearing as classic choroidal neovascularisation on fluorescein angiography</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>91</volume><issue>9</issue><spage>1152</spage><epage>1159</epage><pages>1152-1159</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>Aims:To study the visual prognosis and ocular characteristics of eyes with polypoidal choroidal vasculopathy (PCV) that appear to have classic choroidal neovascularisation (CNV) on fluorescein angiography (FA).Methods:The authors reviewed retrospectively 38 eyes with PCV that appear to have classic CNV on FA. Lesions were examined with indocyanine green angiography, FA and optical coherence tomography (OCT).Results:In all cases OCT showed subretinal material with moderate reflectivity that corresponded in location to classic CNV. At the final visit, the subretinal material resolved completely in 14 eyes (36.8%, resolved group), but resolved only incompletely in 24 eyes (63.2%, persisted group) after photodynamic therapy (PDT). Mean (standard deviation) visual acuity in the resolved group (0.35 (0.41) in log MAR) was significantly better than that in the persisted group (0.84 (0.24)) at the final visit (p<0.001). The subretinal material seen before treatment was more frequently seen in subfovea in the persisted group (87.5% vs 42.9%, p = 0.007). Also, this material was located adjacent to polypoidal lesions more often in the resolved group (92.9% vs 58.3%, p = 0.030).Conclusions:Eyes with PCV sometimes show classic CNV with subretinal material apparent on OCT, and PCV is thus attributed to type 2 CNV or to pure fibrinous tissue without CNV. Visual prognosis in eyes with type 2 CNV is poor, and although it is difficult to discriminate type 2 CNV from pure fibrin deposition before treatment, type 2 CNV is seen more often in the subfovea and is typically separate from the polypoidal lesions.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>17314148</pmid><doi>10.1136/bjo.2006.112318</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Choroid - blood supply Choroidal Neovascularization - diagnosis Choroidal Neovascularization - physiopathology Clinical Science - Extended Report Diagnosis, Differential Female Fluorescein Angiography Humans Lasers Macular degeneration Male Medical imaging Middle Aged Myopia Peripheral Vascular Diseases - diagnosis Peripheral Vascular Diseases - drug therapy Peripheral Vascular Diseases - physiopathology Photochemotherapy Prognosis Retrospective Studies Tomography, Optical Coherence Visual Acuity |
| title | Polypoidal choroidal vasculopathy appearing as classic choroidal neovascularisation on fluorescein angiography |
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