Tests of the Extension and Deadbolt Models of Integrin Activation

Despite extensive evidence that integrin conformational changes between bent and extended conformations regulate affinity for ligands, an alternative hypothesis has been proposed in which a “deadbolt” can regulate affinity for ligand in the absence of extension. Here, we tested both the deadbolt and...

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Veröffentlicht in:	The Journal of biological chemistry 2007-04, Vol.282 (16), p.11914-11920
Hauptverfasser:	Zhu, Jieqing, Boylan, Brian, Luo, Bing-Hao, Newman, Peter J., Springer, Timothy A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Membrane - metabolism CHO Cells Cricetinae Cricetulus Fibronectins - metabolism Humans Integrin alphaV - metabolism Integrin beta3 - metabolism Integrins - metabolism Ligands Mutation Platelet Membrane Glycoprotein IIb - chemistry Protein Binding Protein Structure, Tertiary
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