A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis

Abstract An adaptive mutation (E249G) within West Nile virus (WNV) NS4B gene was consistently recovered from replicon RNAs in C3H/He mouse cells. The E249G is located at the C-terminal tail of NS4B predicted to be on the cytoplasmic side of the endoplasmic reticulum membrane. The E249G substitution...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2007-04, Vol.361 (1), p.229-241
Hauptverfasser:	Puig-Basagoiti, Francesc, Tilgner, Mark, Bennett, Corey J, Zhou, Yangsheng, Muñoz-Jordán, Jorge L, García-Sastre, Adolfo, Bernard, Kristen A, Shi, Pei-Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological amino acid sequences Animals Cell Line Female Flavivirus Flavivirus replication Infectious Disease Interferon-beta - pharmacology Mice Mice, Inbred C3H molecular sequence data Mutation NS4B RNA, Viral - biosynthesis structure-activity relationships Viral Nonstructural Proteins - genetics viral proteins virus replication Virus Replication - drug effects West Nile Fever - prevention & control West Nile Fever - virology West Nile virus West Nile virus - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!