Yeast cells lacking the CIT1-encoded mitochondrial citrate synthase are hypersusceptible to heat- or aging-induced apoptosis

In Saccharomyces cerevisiae, the initial reaction of the tricarboxylic acid cycle is catalyzed by the mitochondrial citrate synthase Cit1. The function of Cit1 has previously been studied mainly in terms of acetate utilization and metabolon construction. Here, we report the relationship between the...

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Veröffentlicht in:	Molecular biology of the cell 2007-09, Vol.18 (9), p.3556-3567
Hauptverfasser:	Lee, Yong Joo, Hoe, Kwang Lae, Maeng, Pil Jae
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Biological Transport - drug effects Biomarkers - metabolism Caspase Inhibitors Caspases Citrate (si)-Synthase - deficiency DNA Fragmentation - drug effects Enzyme Inhibitors - pharmacology Gene Deletion Glutamates - metabolism Glutathione - metabolism Heat-Shock Response - drug effects Hot Temperature Mitochondria - drug effects Mitochondria - enzymology Phenotype Phosphatidylserines - metabolism Reactive Oxygen Species - metabolism Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae Proteins - antagonists & inhibitors Time Factors
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