B cell activator PAX5 promotes lymphomagenesis through stimulation of B cell receptor signaling

The presumed involvement of paired box gene 5 (PAX5) in B-lymphomagenesis is based largely on the discovery of Pax5-specific translocations and somatic hypermutations in non-Hodgkin lymphomas. Yet mechanistically, the contribution of Pax5 to neoplastic growth remains undeciphered. Here we used 2 Myc...

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Veröffentlicht in:	The Journal of clinical investigation 2007-09, Vol.117 (9), p.2602-2610
Hauptverfasser:	Cozma, Diana, Yu, Duonan, Hodawadekar, Suchita, Azvolinsky, Anna, Grande, Shannon, Tobias, John W, Metzgar, Michele H, Paterson, Jennifer, Erikson, Jan, Marafioti, Teresa, Monroe, John G, Atchison, Michael L, Thomas-Tikhonenko, Andrei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - immunology B-Lymphocytes - metabolism Biomedical research Causes of Cell Line, Tumor Cell Proliferation Cell research Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Cells Gene Expression Regulation, Neoplastic Humans Kinases Leukemia Lymphocyte Activation - immunology Lymphoma Lymphoma - genetics Lymphoma - immunology Lymphoma - metabolism Lymphoma - pathology Lymphomas Mice Mutation Neoplasm Transplantation Observations PAX5 Transcription Factor - genetics PAX5 Transcription Factor - metabolism Physiological aspects Proteins Receptors, Antigen, B-Cell - metabolism Signal Transduction Transcription factors Tumors
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