Mapping and phenotypic analysis of spontaneous isatin-β-thiosemicarbazone resistant mutants of vaccinia virus

Abstract Treatment of wild type vaccinia virus infected cells with the anti-poxviral drug isatin-β-thiosemicarbazone (IBT) induces the viral postreplicative transcription apparatus to synthesize longer-than-normal mRNAs through an unknown mechanism. Previous studies have shown that virus mutants res...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2007-07, Vol.363 (2), p.319-332
Hauptverfasser:	Cresawn, Steven G, Prins, Cindy, Latner, Donald R, Condit, Richard C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catalytic Domain - genetics Cell Line DNA-Directed RNA Polymerases - chemistry DNA-Directed RNA Polymerases - genetics Drug resistance Drug Resistance, Viral Gene Expression Profiling Gene Expression Regulation, Viral Genetics Humans Infectious Disease Isatin - analogs & derivatives Isatin - pharmacology Isatin-β-thiosemicarbazone Marker rescue Models, Chemical Mutation Peptide Elongation Factors Phenotype RNA polymerase RNA, Messenger - metabolism RNA, Viral - metabolism Transcription Transcriptional Elongation Factors - genetics Vaccinia virus Vaccinia virus - drug effects Vaccinia virus - genetics Viral Proteins - chemistry Viral Proteins - genetics
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