Purification and characterization of insulin-mimetic inositol phosphoglycan-like molecules from grass pea (Lathyrus sativus) seeds

Signal transduction through the hydrolysis of glycosyl-phosphatidylinositol (GPI) leading to the release of the water-soluble inositol phosphoglycan (IPG) molecules has been demonstrated to be important for mediating some of the actions of insulin and insulin-like growth factor-I (IGF-I). In the pre...

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Veröffentlicht in:	Molecular medicine (Cambridge, Mass.) Mass.), 2001-07, Vol.7 (7), p.454-460
Hauptverfasser:	Pañeda, C, Villar, A V, Alonso, A, Goñi, F M, Varela, F, Brodbeck, U, León, Y, Varela-Nieto, I, Jones, D R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division - drug effects Cell Line Chick Embryo Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Fatty Acids - analysis Ganglia - cytology Ganglia - drug effects Gene Expression - drug effects Glycosylphosphatidylinositols - chemistry Glycosylphosphatidylinositols - isolation & purification Glycosylphosphatidylinositols - pharmacology Hydrolysis In Vitro Techniques Inositol Phosphates - chemistry Inositol Phosphates - isolation & purification Inositol Phosphates - pharmacology Insulin - pharmacology Lathyrus - chemistry Liver - drug effects Liver - enzymology Phosphoenolpyruvate Carboxykinase (GTP) - antagonists & inhibitors Polysaccharides - chemistry Polysaccharides - isolation & purification Polysaccharides - pharmacology Rats Seeds - chemistry
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