Dual transcriptional activities underlie opposing effects of retinoic acid on cell survival

Transcriptional activation of the nuclear receptor RAR by retinoic acid (RA) often leads to inhibition of cell growth. However, in some tissues, RA promotes cell survival and hyperplasia, activities that are unlikely to be mediated by RAR. Here we show that, in addition to functioning through RAR, R...

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Veröffentlicht in:	Cell 2007-05, Vol.129 (4), p.723-733
Hauptverfasser:	Schug, Thaddeus T, Berry, Daniel C., Shaw, Natacha S., Travis, Skylar N., Noy, Noa
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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