Inhibition by the chromaffin cell-derived peptide serine-histogranin in the rat's dorsal horn

The heptadecapeptide histogranin, synthesized by adrenal chromaffin cells, is implicated in the analgesia produced by transplanting chromaffin cells into the spinal cord, including block of hyperalgesia mediated by NMDA-subtype glutamate receptors. To examine the neurophysiological basis for this an...

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Veröffentlicht in:	Neuroscience letters 2007-05, Vol.419 (1), p.88-92
Hauptverfasser:	Hentall, Ian D., Hargraves, Walter A., Sagen, Jacqueline
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Analgesia Animals Biological and medical sciences Dose-Response Relationship, Drug Drug Interactions Electric Stimulation Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acids - pharmacology Female Fundamental and applied biological sciences. Psychology In Vitro Techniques Kainate Neural Inhibition - drug effects NMDA Nociception Posterior Horn Cells - drug effects Proteins - pharmacology Rats Rats, Sprague-Dawley Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal Cord - cytology Time Factors Vertebrates: nervous system and sense organs Wind-up
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