Low affinity binding of the classical D1 antagonist SCH23390 in rodent brain : Potential interaction with A2A and D2-like receptors

Whereas structurally dissimilar D(1) antagonists competing for [(3)H]-SCH23390 binding recognize primarily one site in striatum, two distinct affinity states are observed in both amygdala and hippocampus. The binding profile of SCH23390 is similar in both of these regions, with the high affinity sit...

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Veröffentlicht in:	Brain research 2006-10, Vol.1117 (1), p.25-37
Hauptverfasser:	LEONARD, Sarah K, FERRY-LEEPER, Penelope, MAILMAN, Richard B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - metabolism Animals Benzazepines - metabolism Benzazepines - pharmacology Binding Sites - drug effects Binding Sites - genetics Binding, Competitive - drug effects Binding, Competitive - genetics Biological and medical sciences Brain - anatomy & histology Brain - drug effects Brain - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Domperidone - pharmacology Dopamine - metabolism Dopamine - pharmacology Dopamine Antagonists - metabolism Dopamine Antagonists - pharmacology Female Fundamental and applied biological sciences. Psychology HeLa Cells Humans Magnesium Chloride - pharmacology Male Mice Mice, Inbred C57BL Mice, Knockout Radioligand Assay Rats Receptor Aggregation - drug effects Receptor Aggregation - genetics Receptor, Adenosine A2A - drug effects Receptor, Adenosine A2A - genetics Receptor, Adenosine A2A - metabolism Receptors, Dopamine D1 - drug effects Receptors, Dopamine D1 - genetics Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - drug effects Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - metabolism Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism Vertebrates: nervous system and sense organs
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