In vitro Activation of Stat3 by Epidermal Growth Factor Receptor Kinase

Stat proteins are SH2 domain-containing transcription factors that are activated in cells by various cytokines and growth factors. In the case of cytokines whose receptors lack protein kinase activity, phosphorylation-activation is mediated by members of the JAK family of tyrosine protein kinases. I...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1996-11, Vol.93 (24), p.13704-13708
Hauptverfasser: Park, Ohkmae K., Schaefer, Timothy S., Nathans, Daniel
Format: Artikel
Sprache:eng
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