Minocycline Inhibits Caspase-Independent and -Dependent Mitochondrial Cell Death Pathways in Models of Huntington's Disease

Minocycline is broadly protective in neurologic disease models featuring cell death and is being evaluated in clinical trials. We previously demonstrated that minocycline-mediated protection against caspase-dependent cell death related to its ability to prevent mitochondrial cytochrome c release. Th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-09, Vol.100 (18), p.10483-10487
Hauptverfasser:	Wang, Xin, Zhu, Shan, Drozda, Martin, Zhang, Wenhua, Stavrovskaya, Irina G., Cattaneo, Elena, Ferrante, Robert J., Kristal, Bruce S., Friedlander, Robert M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies BH3 Interacting Domain Death Agonist Protein Biological Sciences Carrier Proteins - metabolism Caspase Inhibitors Caspases - physiology Cell death Cell Death - drug effects Cell Line Cells Clinical trials Cyclosporins Cytochromes Disease Disease models Disease Models, Animal Drugs Humans Huntington disease Huntington Disease - drug therapy Huntington Disease - pathology Medical schools Mice minocycline Minocycline - pharmacology Mitochondria Mitochondria - drug effects Mitochondria - physiology Neurology Neurons Neuroprotective Agents - pharmacology Swelling Tumor Necrosis Factor-alpha - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!