Miniaturized PCR chips for nucleic acid amplification and analysis: latest advances and future trends
The possibility of performing fast and small-volume nucleic acid amplification and analysis on a single chip has attracted great interest. Devices based on this idea, referred to as micro total analysis, microfluidic analysis, or simply 'Lab on a chip' systems, have witnessed steady advanc...
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| Veröffentlicht in: | Nucleic acids research 2007-07, Vol.35 (13), p.4223-4237 |
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| container_title | Nucleic acids research |
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| creator | Zhang, Chunsun Xing, Da |
| description | The possibility of performing fast and small-volume nucleic acid amplification and analysis on a single chip has attracted great interest. Devices based on this idea, referred to as micro total analysis, microfluidic analysis, or simply 'Lab on a chip' systems, have witnessed steady advances over the last several years. Here, we summarize recent research on chip substrates, surface treatments, PCR reaction volume and speed, architecture, approaches to eliminating cross-contamination and control and measurement of temperature and liquid flow. We also discuss product-detection methods, integration of functional components, biological samples used in PCR chips, potential applications and other practical issues related to implementation of lab-on-a-chip technologies. |
| doi_str_mv | 10.1093/nar/gkm389 |
| format | Article |
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| ispartof | Nucleic acids research, 2007-07, Vol.35 (13), p.4223-4237 |
| issn | 0305-1048 1362-4962 |
| language | eng |
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| source | Oxford Journals Open Access Collection |
| subjects | Adsorption DNA, Bacterial - analysis DNA, Viral - analysis Microfluidic Analytical Techniques - instrumentation Microfluidic Analytical Techniques - trends Polymerase Chain Reaction - instrumentation Polymerase Chain Reaction - trends Survey and Summary Temperature Time Factors |
| title | Miniaturized PCR chips for nucleic acid amplification and analysis: latest advances and future trends |
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