Functional NADPH Oxidase Prevents Caspase Involvement in the Clearance of Phagocytic Neutrophils

Neutrophils play a prominent role in host defense. Phagocytosis of bacteria leads to the formation of an active NADPH oxidase complex that generates reactive oxygen species for bactericidal purposes. A critical step in the resolution of inflammation is the uptake of neutrophils by macrophages; howev...

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Veröffentlicht in:	Infection and Immunity 2007-07, Vol.75 (7), p.3256-3263
Hauptverfasser:	Wilkie, Rachel P, Vissers, Margret C.M, Dragunow, Mike, Hampton, Mark B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Biological and medical sciences Caspase 3 - metabolism Caspase Inhibitors Caspases - metabolism Enzyme Activation - drug effects Fundamental and applied biological sciences. Psychology Host Response and Inflammation Humans Inflammation Macrophages - immunology Membrane Glycoproteins - genetics Mice Mice, Inbred C57BL Mice, Knockout Molecular and cellular biology NADPH Oxidase 2 NADPH Oxidases - genetics NADPH Oxidases - metabolism NADPH Oxidases - pharmacology Neutrophils - enzymology Neutrophils - immunology Neutrophils - microbiology Phagocytosis - immunology Phosphatidylserines - pharmacology Staphylococcus aureus Staphylococcus aureus - immunology
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