STUDIES ON INHIBITION OF INTESTINAL ABSORPTION OF RADIOACTIVE STRONTIUM. II. EFFECTS OF ADMINISTRATION OF SODIUM ALGINATE BY OROGASTRIC INTUBATION AND FEEDING
A method is reported that enables selective suppression of absorption of radioactive strontium from ingested food material, permitting calcium to remain available to the body. Studies were carried out by measuring blood levels and bone uptake of Sr(89) and Ca(45) at different time intervals after or...
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| Veröffentlicht in: | Canadian Medical Association journal 1964-09, Vol.91 (10), p.553-557 |
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| creator | PAUL, T M EDWARD, D W SKORYNA, S C |
| description | A method is reported that enables selective suppression of absorption of radioactive strontium from ingested food material, permitting calcium to remain available to the body. Studies were carried out by measuring blood levels and bone uptake of Sr(89) and Ca(45) at different time intervals after orogastric intubation of rats. The addition of sodium alginate, derived from brown marine algae, to the radioactive isotopes increased the overall physiological discrimination against strontium by amounts up to 60% after 24 hours. This discrimination was further increased by feeding sodium alginate mixed with standard diet in the proportions of 20:80 and 30:70. The observed ratio was reduced by administration of sodium alginate from 0.25 to 0.09.Determination of the limiting dosage in rats is restricted to the amounts which rats will consume. In the event of an inadvertent release of radioactive strontium, human subjects probably could increase their intake of alginate at will, permitting a greater effectiveness of sodium alginate than could be obtained in experimental animals. |
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II. EFFECTS OF ADMINISTRATION OF SODIUM ALGINATE BY OROGASTRIC INTUBATION AND FEEDING</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>PAUL, T M ; EDWARD, D W ; SKORYNA, S C</creator><creatorcontrib>PAUL, T M ; EDWARD, D W ; SKORYNA, S C</creatorcontrib><description>A method is reported that enables selective suppression of absorption of radioactive strontium from ingested food material, permitting calcium to remain available to the body. Studies were carried out by measuring blood levels and bone uptake of Sr(89) and Ca(45) at different time intervals after orogastric intubation of rats. The addition of sodium alginate, derived from brown marine algae, to the radioactive isotopes increased the overall physiological discrimination against strontium by amounts up to 60% after 24 hours. This discrimination was further increased by feeding sodium alginate mixed with standard diet in the proportions of 20:80 and 30:70. The observed ratio was reduced by administration of sodium alginate from 0.25 to 0.09.Determination of the limiting dosage in rats is restricted to the amounts which rats will consume. In the event of an inadvertent release of radioactive strontium, human subjects probably could increase their intake of alginate at will, permitting a greater effectiveness of sodium alginate than could be obtained in experimental animals.</description><identifier>ISSN: 0008-4409</identifier><identifier>PMID: 14176062</identifier><language>eng</language><publisher>Canada</publisher><subject>Absorption ; Alginates ; Animals ; Blood ; Bone and Bones ; Calcium Isotopes ; Diet ; Glucuronic Acid ; Hexuronic Acids ; Humans ; Intestinal Absorption ; Intestines ; Intubation ; Old Medline ; Original ; Radiation-Protective Agents ; Radioactivity ; Radioisotopes ; Radionuclide Imaging ; Rats ; Strontium ; Strontium Isotopes</subject><ispartof>Canadian Medical Association journal, 1964-09, Vol.91 (10), p.553-557</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1927926/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1927926/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14176062$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PAUL, T M</creatorcontrib><creatorcontrib>EDWARD, D W</creatorcontrib><creatorcontrib>SKORYNA, S C</creatorcontrib><title>STUDIES ON INHIBITION OF INTESTINAL ABSORPTION OF RADIOACTIVE STRONTIUM. II. EFFECTS OF ADMINISTRATION OF SODIUM ALGINATE BY OROGASTRIC INTUBATION AND FEEDING</title><title>Canadian Medical Association journal</title><addtitle>Can Med Assoc J</addtitle><description>A method is reported that enables selective suppression of absorption of radioactive strontium from ingested food material, permitting calcium to remain available to the body. Studies were carried out by measuring blood levels and bone uptake of Sr(89) and Ca(45) at different time intervals after orogastric intubation of rats. The addition of sodium alginate, derived from brown marine algae, to the radioactive isotopes increased the overall physiological discrimination against strontium by amounts up to 60% after 24 hours. This discrimination was further increased by feeding sodium alginate mixed with standard diet in the proportions of 20:80 and 30:70. The observed ratio was reduced by administration of sodium alginate from 0.25 to 0.09.Determination of the limiting dosage in rats is restricted to the amounts which rats will consume. In the event of an inadvertent release of radioactive strontium, human subjects probably could increase their intake of alginate at will, permitting a greater effectiveness of sodium alginate than could be obtained in experimental animals.</description><subject>Absorption</subject><subject>Alginates</subject><subject>Animals</subject><subject>Blood</subject><subject>Bone and Bones</subject><subject>Calcium Isotopes</subject><subject>Diet</subject><subject>Glucuronic Acid</subject><subject>Hexuronic Acids</subject><subject>Humans</subject><subject>Intestinal Absorption</subject><subject>Intestines</subject><subject>Intubation</subject><subject>Old Medline</subject><subject>Original</subject><subject>Radiation-Protective Agents</subject><subject>Radioactivity</subject><subject>Radioisotopes</subject><subject>Radionuclide Imaging</subject><subject>Rats</subject><subject>Strontium</subject><subject>Strontium Isotopes</subject><issn>0008-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1964</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkd9OgzAUxrnQuDl9BdMr7zAFOv7cmBQorAmjBoqJV6Swohg2JmwmvozPapdtRq96mu93vu-cnAttCiF0dYSgN9Gux_EdQtMyIbrSJgYyHBva5lT7znkRUpIDlgKaLqhPOVUli9SPk5zTFCcA-znLns5ChkPKcMDpMwE5z1jKabF8AJQ-ABJFJOD5gcLhkqZU6fjcl7NQgQAnsTLlBPgvgGUsxoqhwSGu8I8sTkMQERLSNL7RLhvRjfL29M60IiI8WOgJi2mAE31rQM_W0byBblWZrjUXK0siw61rByKjQXVtIxOZtgVlhSzPdYQhXM-pHVet70kTNWJlC2umPR59t_tqLVe13OwG0ZXboV2L4avsRVv-VzbtW_naf5aGZzqesp9p9yeDof_Yy3FXrtuxll0nNrLfj6WazHYMeADv_ib9RpxPYv0Axbd7RA</recordid><startdate>19640905</startdate><enddate>19640905</enddate><creator>PAUL, T M</creator><creator>EDWARD, D W</creator><creator>SKORYNA, S C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19640905</creationdate><title>STUDIES ON INHIBITION OF INTESTINAL ABSORPTION OF RADIOACTIVE STRONTIUM. II. EFFECTS OF ADMINISTRATION OF SODIUM ALGINATE BY OROGASTRIC INTUBATION AND FEEDING</title><author>PAUL, T M ; EDWARD, D W ; SKORYNA, S C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1096-45f08bb2835ad3e418cc7041f4cc64242630eb43987a1a897c780629e24fad6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1964</creationdate><topic>Absorption</topic><topic>Alginates</topic><topic>Animals</topic><topic>Blood</topic><topic>Bone and Bones</topic><topic>Calcium Isotopes</topic><topic>Diet</topic><topic>Glucuronic Acid</topic><topic>Hexuronic Acids</topic><topic>Humans</topic><topic>Intestinal Absorption</topic><topic>Intestines</topic><topic>Intubation</topic><topic>Old Medline</topic><topic>Original</topic><topic>Radiation-Protective Agents</topic><topic>Radioactivity</topic><topic>Radioisotopes</topic><topic>Radionuclide Imaging</topic><topic>Rats</topic><topic>Strontium</topic><topic>Strontium Isotopes</topic><toplevel>online_resources</toplevel><creatorcontrib>PAUL, T M</creatorcontrib><creatorcontrib>EDWARD, D W</creatorcontrib><creatorcontrib>SKORYNA, S C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Canadian Medical Association journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PAUL, T M</au><au>EDWARD, D W</au><au>SKORYNA, S C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>STUDIES ON INHIBITION OF INTESTINAL ABSORPTION OF RADIOACTIVE STRONTIUM. II. EFFECTS OF ADMINISTRATION OF SODIUM ALGINATE BY OROGASTRIC INTUBATION AND FEEDING</atitle><jtitle>Canadian Medical Association journal</jtitle><addtitle>Can Med Assoc J</addtitle><date>1964-09-05</date><risdate>1964</risdate><volume>91</volume><issue>10</issue><spage>553</spage><epage>557</epage><pages>553-557</pages><issn>0008-4409</issn><abstract>A method is reported that enables selective suppression of absorption of radioactive strontium from ingested food material, permitting calcium to remain available to the body. Studies were carried out by measuring blood levels and bone uptake of Sr(89) and Ca(45) at different time intervals after orogastric intubation of rats. The addition of sodium alginate, derived from brown marine algae, to the radioactive isotopes increased the overall physiological discrimination against strontium by amounts up to 60% after 24 hours. This discrimination was further increased by feeding sodium alginate mixed with standard diet in the proportions of 20:80 and 30:70. The observed ratio was reduced by administration of sodium alginate from 0.25 to 0.09.Determination of the limiting dosage in rats is restricted to the amounts which rats will consume. In the event of an inadvertent release of radioactive strontium, human subjects probably could increase their intake of alginate at will, permitting a greater effectiveness of sodium alginate than could be obtained in experimental animals.</abstract><cop>Canada</cop><pmid>14176062</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Canadian Medical Association journal, 1964-09, Vol.91 (10), p.553-557 |
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| subjects | Absorption Alginates Animals Blood Bone and Bones Calcium Isotopes Diet Glucuronic Acid Hexuronic Acids Humans Intestinal Absorption Intestines Intubation Old Medline Original Radiation-Protective Agents Radioactivity Radioisotopes Radionuclide Imaging Rats Strontium Strontium Isotopes |
| title | STUDIES ON INHIBITION OF INTESTINAL ABSORPTION OF RADIOACTIVE STRONTIUM. II. EFFECTS OF ADMINISTRATION OF SODIUM ALGINATE BY OROGASTRIC INTUBATION AND FEEDING |
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