Cyclin A Cdk2 complexes regulate activation of Cdk1 and Cdc25 phosphatases in human cells

Mitotic entry, a critical decision point for maintaining genetic stability, is governed by the cyclin B/Cyclin dependent kinase 1 (Cdc2) complex. In Xenopus oocytes and early embryos, accumulation of cyclin B activates Cdk1, which then phosphorylates and activates the positive regulator Cdc25 in an...

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Veröffentlicht in:	Oncogene 2004-04, Vol.23 (19), p.3361-3367
Hauptverfasser:	Mitra, Jayashree, Enders, Greg H
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cdc2 protein CDC2 Protein Kinase - metabolism CDC2-CDC28 Kinases - physiology cdc25 Phosphatases - metabolism Cdc25B phosphatase Cell activation Cell cycle Cells, Cultured Cyclin A Cyclin A - physiology Cyclin B Cyclin-Dependent Kinase 2 Dephosphorylation Embryos Enzyme Activation Fibroblasts G2 Phase Humans Kinases Mitosis Oocytes Phosphatase Phosphorylation RNA-mediated interference S Phase Tyrosine Xenopus
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