A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma

RMP-7, a bradykinin analog, temporarily increases the permeability of the blood-brain tumor barrier to chemotherapy drugs like carboplatin. We conducted a randomized, controlled trial of carboplatin and RMP-7 versus carboplatin and placebo in patients with recurrent malignant glioma. The primary out...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2003-04, Vol.5 (2), p.96-103
Hauptverfasser:	Prados, Michael D, Schold, Jr, S Clifford, Fine, Howard A, Jaeckle, Kurt, Hochberg, Fred, Mechtler, Laszlo, Fetell, Michael R, Phuphanich, Surasak, Feun, Lynn, Janus, Todd J, Ford, Kathleen, Graney, William
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - administration & dosage Area Under Curve Bradykinin - administration & dosage Bradykinin - analogs & derivatives Carboplatin - administration & dosage Confidence Intervals Double-Blind Method Female Glioblastoma - drug therapy Glioblastoma - mortality Glioma - drug therapy Glioma - mortality Humans Infusions, Intravenous Male Middle Aged Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - mortality Proportional Hazards Models Survival Rate
Online-Zugang:	Volltext
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