Endostatin reduces vascularization, blood flow, and growth in a rat gliosarcoma

Endostatin, the 20-kDa C-terminal fragment of collagen XVIII, has previously been shown to inhibit growth and induce regression of different experimental tumors in rodents. In this study, we show that recombinant murine and human endostatin, produced in 293 EBNA cells and yeast, respectively, inhibi...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2002-01, Vol.4 (1), p.1-8
Hauptverfasser:	Sorensen, Dag R, Read, Tracy-Ann, Porwol, Torsten, Olsen, Bjorn Reino, Timpl, Rupert, Sasaki, Takako, Iversen, Per O, Benestad, Haakon B, Sim, B Kim Lee, Bjerkvig, Rolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - pharmacology Animals Apoptosis Brain Neoplasms - blood supply Brain Neoplasms - pathology Brain Neoplasms - physiopathology Collagen - pharmacology Collagen Type XVIII Endostatins Fluorescent Antibody Technique Gliosarcoma - blood supply Gliosarcoma - pathology Gliosarcoma - physiopathology Humans Mice Microscopy, Confocal Microscopy, Fluorescence Neoplasm Transplantation Neovascularization, Pathologic - pathology Peptide Fragments - pharmacology Rats Rats, Inbred Strains Regional Blood Flow - drug effects Skin Neoplasms Tumor Cells, Cultured
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