Synthesis and investigation of deoxyribonucleic acid/locked nucleic acid chimeric molecular beacons

To take full advantage of locked nucleic acid (LNA) based molecular beacons (LNA-MBs) for a variety of applications including analysis of complex samples and intracellular monitoring, we have systematically synthesized a series of DNA/LNA chimeric MBs and studied the effect of DNA/LNA ratio in MBs o...

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Veröffentlicht in:	Nucleic acids research 2007-06, Vol.35 (12), p.4030-4041
Hauptverfasser:	Yang, Chaoyong James, Wang, Lin, Wu, Yanrong, Kim, Youngmi, Medley, Colin D, Lin, Hui, Tan, Weihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Deoxyribonuclease I - metabolism DNA Probes - chemistry DNA, Complementary - chemistry DNA-Binding Proteins - metabolism Fluorescent Dyes - chemistry Kinetics Molecular Biology Nucleic Acid Hybridization Oligonucleotide Probes - chemical synthesis Oligonucleotide Probes - chemistry Oligonucleotide Probes - metabolism Oligonucleotides Oligonucleotides, Antisense - chemistry Oligonucleotides, Antisense - metabolism Ribonuclease H - metabolism Thermodynamics
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