Rad51 and Rad54 ATPase activities are both required to modulate Rad51-dsDNA filament dynamics

Rad51 and Rad54 are key proteins that collaborate during homologous recombination. Rad51 forms a presynaptic filament with ATP and ssDNA active in homology search and DNA strand exchange, but the precise role of its ATPase activity is poorly understood. Rad54 is an ATP-dependent dsDNA motor protein...

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Veröffentlicht in:	Nucleic acids research 2007-06, Vol.35 (12), p.4124-4140
Hauptverfasser:	Li, Xuan, Zhang, Xiao-Ping, Solinger, Jachen A, Kiianitsa, Konstantin, Yu, Xiong, Egelman, Edward H, Heyer, Wolf-Dietrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Adenosine Triphosphate - metabolism Amino Acid Substitution DNA - chemistry DNA - metabolism DNA - ultrastructure DNA Helicases DNA Repair Enzymes DNA, Superhelical - analysis Nucleic Acid Enzymes Rad51 Recombinase - genetics Rad51 Recombinase - isolation & purification Rad51 Recombinase - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - isolation & purification Saccharomyces cerevisiae Proteins - metabolism
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