Replication of genetic linkage by follow-up of previously studied pedigrees

Independent replication of linkage in previously studied pedigrees is desirable when genetic heterogeneity is suspected or when the illness is very rare. When the likelihood of the new data in this type of replication study is computed as conditional on the previously reported linkage results, it ca...

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Veröffentlicht in:	American journal of human genetics 1994-04, Vol.54 (4), p.715-718
Hauptverfasser:	GERSHON, E. S, GOLDIN, L. R
Format:	Artikel
Sprache:	eng
Schlagworte:	990200 > Mathematics & Computers BASIC BIOLOGICAL SCIENCES Biological and medical sciences Classical genetics, quantitative genetics, hybrids computer programs Computer Simulation COMPUTERIZED SIMULATION DISEASES Female Fundamental and applied biological sciences. Psychology GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE Genetic Diseases, Inborn - genetics Genetic Linkage GENETIC MAPPING Genetics of eukaryotes. Biological and molecular evolution genotype Humans Likelihood Functions linkage Lod Score Male man MAPPING MATHEMATICS Methods, theories and miscellaneous Models, Genetic Pedigree Reproducibility of Results SIMULATION 550400 > Genetics Software STATISTICS
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