Selective and competitive antagonism by suramin of ATP‐stimulated catecholamine‐secretion from PC12 phaeochromocytoma cells

1 Suramin, a putative P2‐antagonist, (10 to 300 μm) inhibited the adenosine 5′‐triphosphate (ATP)‐stimulated secretion of [3H]‐noradrenaline or endogenous dopamine from phaeochromocytoma PC12 cells in a concentration‐dependent manner. Suramin (300 μm) did not affect the dopamine‐secretion stimulated...

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Veröffentlicht in:	British journal of pharmacology 1991-03, Vol.102 (3), p.581-584
Hauptverfasser:	Inoue, Kazuhide, Nakazawa, Ken, Ohara‐Imaizumi, Mica, Obama, Tomoko, Fujimori, Kannosuke, Takanaka, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - antagonists & inhibitors Animals Biological and medical sciences Calcium - metabolism Catecholamines - metabolism Cell physiology Fundamental and applied biological sciences. Psychology Molecular and cellular biology PC12 Cells Rats Secretion. Exocytosis Suramin - pharmacology
Online-Zugang:	Volltext
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