Effects of glibenclamide on cytosolic calcium concentrations and on contraction of the rabbit aorta

1 Using fluorometry of fura‐2 and rabbit aortic strips, we studied the effects of glibenclamide (GLB), a sulphonylurea anti‐diabetic drug and an inhibitor of opening of K+ channels, on cytosolic calcium concentrations ([Ca2+]i) and on force development. 2 Both high K+‐depolarization and noradrenalin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of pharmacology 1991-01, Vol.102 (1), p.113-118
Hauptverfasser:	Yoshitake, Kiyonobu, Hirano, Katsuya, Kanaide, Hideo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic - drug effects Benzopyrans - pharmacology Biological and medical sciences Calcium - metabolism Cardiovascular system Cromakalim Cytosol - metabolism Fura-2 Glyburide - pharmacology In Vitro Techniques Male Medical sciences Miscellaneous Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Norepinephrine - pharmacology Pharmacology. Drug treatments Potassium - pharmacology Pyrroles - pharmacology Rabbits
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!