Selective chiral inhibitors of 5‐lipoxygenase with anti‐inflammatory activity

The studies described here, using enantiomers of an optically‐active methoxy alkyl thiazole ICI216800 (1‐methoxy‐6‐(naphth‐2‐yl‐methoxy)‐1‐(thiazol‐2‐yl)indane), provide unequivocal evidence for a specific, chiral interaction with 5‐lipoxygenase. In accordance with their biochemical efficacy these c...

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Veröffentlicht in:	British journal of pharmacology 1990-11, Vol.101 (3), p.501-503
Hauptverfasser:	McMillan, R.M., Girodeau, J.‐M., Foster, S.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology antiinflammatory agents Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Eicosanoids - biosynthesis Humans In Vitro Techniques Indans - pharmacology Inflammation - drug therapy Leukotriene B4 - biosynthesis Lipoxygenase Inhibitors Medical sciences Pharmacology. Drug treatments Rabbits Rats Stereoisomerism Thiazoles - pharmacology
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