Evidence that an atypical β‐adrenoceptor mediates the inhibition of spontaneous rhythmical contractions of rabbit isolated jejunum induced by ritodrine and salbutamol
1 The nature of the adrenoceptors mediating the inhibitory action of noradrenaline, ritodrine and salbutamol on the spontaneous activity of longitudinal muscle of the rabbit jejunum in vitro was investigated by use of a range of adrenoceptor antagonists. 2 The actions of ritodrine and salbutamol wer...
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| Veröffentlicht in: | British journal of pharmacology 1990-09, Vol.101 (1), p.27-30 |
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| creator | Norman, Bernard J. Leathard, Helen L. |
| description | 1
The nature of the adrenoceptors mediating the inhibitory action of noradrenaline, ritodrine and salbutamol on the spontaneous activity of longitudinal muscle of the rabbit jejunum in vitro was investigated by use of a range of adrenoceptor antagonists.
2
The actions of ritodrine and salbutamol were antagonized competitively by propranolol. The pA2 values of 6.4 and 6.6 respectively were smaller than those found elsewhere for β1‐ and β2‐adrenoceptors.
3
In contrast, the responses to ritodrine and salbutamol were antagonized only by high concentrations (>2.7 μm) of phentolamine and were unaffected by yohimbine (2.6 μm), mepyramine (2.5 μm) or cimetidine (4.0 μm).
4
Ritodrine which is less potent than salbutamol in tissues with typical β2‐adrenoceptors was found to be 8 times more potent than salbutamol in the rabbit jejunum.
5
It is suggested that in the rabbit jejunum ritodrine and salbutamol may act at an atypical β‐adrenoceptor, at which propranolol is a competitive but not very potent antagonist. |
| doi_str_mv | 10.1111/j.1476-5381.1990.tb12083.x |
| format | Article |
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The nature of the adrenoceptors mediating the inhibitory action of noradrenaline, ritodrine and salbutamol on the spontaneous activity of longitudinal muscle of the rabbit jejunum in vitro was investigated by use of a range of adrenoceptor antagonists.
2
The actions of ritodrine and salbutamol were antagonized competitively by propranolol. The pA2 values of 6.4 and 6.6 respectively were smaller than those found elsewhere for β1‐ and β2‐adrenoceptors.
3
In contrast, the responses to ritodrine and salbutamol were antagonized only by high concentrations (>2.7 μm) of phentolamine and were unaffected by yohimbine (2.6 μm), mepyramine (2.5 μm) or cimetidine (4.0 μm).
4
Ritodrine which is less potent than salbutamol in tissues with typical β2‐adrenoceptors was found to be 8 times more potent than salbutamol in the rabbit jejunum.
5
It is suggested that in the rabbit jejunum ritodrine and salbutamol may act at an atypical β‐adrenoceptor, at which propranolol is a competitive but not very potent antagonist.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1990.tb12083.x</identifier><identifier>PMID: 2178019</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Albuterol - pharmacology ; Animals ; Biological and medical sciences ; Cimetidine - pharmacology ; Female ; In Vitro Techniques ; Jejunum - drug effects ; Male ; Medical sciences ; Muscle ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Muscle, Smooth - physiology ; Norepinephrine - pharmacology ; Pharmacology. Drug treatments ; Pyrilamine - pharmacology ; Rabbits ; Receptors, Adrenergic, beta - drug effects ; Receptors, Adrenergic, beta - metabolism ; Ritodrine - pharmacology ; Yohimbine - pharmacology</subject><ispartof>British journal of pharmacology, 1990-09, Vol.101 (1), p.27-30</ispartof><rights>1990 British Pharmacological Society</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5083-1f5b05dfd2bb362b95312e41b4b46554722fb2527c51847be9b14db79545013c3</citedby><cites>FETCH-LOGICAL-c5083-1f5b05dfd2bb362b95312e41b4b46554722fb2527c51847be9b14db79545013c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1917614/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1917614/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19273882$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2178019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Norman, Bernard J.</creatorcontrib><creatorcontrib>Leathard, Helen L.</creatorcontrib><title>Evidence that an atypical β‐adrenoceptor mediates the inhibition of spontaneous rhythmical contractions of rabbit isolated jejunum induced by ritodrine and salbutamol</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
The nature of the adrenoceptors mediating the inhibitory action of noradrenaline, ritodrine and salbutamol on the spontaneous activity of longitudinal muscle of the rabbit jejunum in vitro was investigated by use of a range of adrenoceptor antagonists.
2
The actions of ritodrine and salbutamol were antagonized competitively by propranolol. The pA2 values of 6.4 and 6.6 respectively were smaller than those found elsewhere for β1‐ and β2‐adrenoceptors.
3
In contrast, the responses to ritodrine and salbutamol were antagonized only by high concentrations (>2.7 μm) of phentolamine and were unaffected by yohimbine (2.6 μm), mepyramine (2.5 μm) or cimetidine (4.0 μm).
4
Ritodrine which is less potent than salbutamol in tissues with typical β2‐adrenoceptors was found to be 8 times more potent than salbutamol in the rabbit jejunum.
5
It is suggested that in the rabbit jejunum ritodrine and salbutamol may act at an atypical β‐adrenoceptor, at which propranolol is a competitive but not very potent antagonist.</description><subject>Albuterol - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cimetidine - pharmacology</subject><subject>Female</subject><subject>In Vitro Techniques</subject><subject>Jejunum - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - physiology</subject><subject>Norepinephrine - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrilamine - pharmacology</subject><subject>Rabbits</subject><subject>Receptors, Adrenergic, beta - drug effects</subject><subject>Receptors, Adrenergic, beta - metabolism</subject><subject>Ritodrine - pharmacology</subject><subject>Yohimbine - pharmacology</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUUuO1DAUjBBoaAaOgGQhwS7Bz7E7CQsEjAYGaSRYwNqyHYc4SuzGdobJjiNwDbYchENwEpzpVgNLvLGfq169T2XZI8AFpPN0KIBW25yVNRTQNLiIEgiuy-L6VrY5QrezDca4ygHq-m52L4QB4wRW7CQ7IVDVGJpN9v38yrTaKo1iLyISFom47IwSI_r549fXb6L12jqld9F5NOnWiKhD4mpkbG-kicZZ5DoUds5GYbWbA_L9EvvpRkOlXy_UygorzQuZcpAJbkxCLRr0MNt5SmLtrFIsF-RNdK03VqdmWhTEKOcoJjfez-50Ygz6weE-zT6-Pv9wdpFfvnvz9uzlZa5YWkEOHZOYtV1LpCy3RDasBKIpSCrpljFaEdJJwkilGNS0krqRQFtZNYwyDKUqT7Pne93dLNPASq8TjHznzST8wp0w_F_Emp5_clccGqi2QJPAk4OAd59nHSKfTFB6HPfr4TUmtKbAEvHZnqi8C8Hr7lgEMF-N5gNf3eSrm3w1mh-M5tcp-eHfbR5TD84m_PEBFyE50XlhlQl_KjSkKuuaJN6LPe-LGfXyHx3wV-8vbp7lb0mhzUs</recordid><startdate>199009</startdate><enddate>199009</enddate><creator>Norman, Bernard J.</creator><creator>Leathard, Helen L.</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199009</creationdate><title>Evidence that an atypical β‐adrenoceptor mediates the inhibition of spontaneous rhythmical contractions of rabbit isolated jejunum induced by ritodrine and salbutamol</title><author>Norman, Bernard J. ; Leathard, Helen L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5083-1f5b05dfd2bb362b95312e41b4b46554722fb2527c51847be9b14db79545013c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Albuterol - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cimetidine - pharmacology</topic><topic>Female</topic><topic>In Vitro Techniques</topic><topic>Jejunum - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - physiology</topic><topic>Norepinephrine - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrilamine - pharmacology</topic><topic>Rabbits</topic><topic>Receptors, Adrenergic, beta - drug effects</topic><topic>Receptors, Adrenergic, beta - metabolism</topic><topic>Ritodrine - pharmacology</topic><topic>Yohimbine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Norman, Bernard J.</creatorcontrib><creatorcontrib>Leathard, Helen L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Norman, Bernard J.</au><au>Leathard, Helen L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence that an atypical β‐adrenoceptor mediates the inhibition of spontaneous rhythmical contractions of rabbit isolated jejunum induced by ritodrine and salbutamol</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1990-09</date><risdate>1990</risdate><volume>101</volume><issue>1</issue><spage>27</spage><epage>30</epage><pages>27-30</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>1
The nature of the adrenoceptors mediating the inhibitory action of noradrenaline, ritodrine and salbutamol on the spontaneous activity of longitudinal muscle of the rabbit jejunum in vitro was investigated by use of a range of adrenoceptor antagonists.
2
The actions of ritodrine and salbutamol were antagonized competitively by propranolol. The pA2 values of 6.4 and 6.6 respectively were smaller than those found elsewhere for β1‐ and β2‐adrenoceptors.
3
In contrast, the responses to ritodrine and salbutamol were antagonized only by high concentrations (>2.7 μm) of phentolamine and were unaffected by yohimbine (2.6 μm), mepyramine (2.5 μm) or cimetidine (4.0 μm).
4
Ritodrine which is less potent than salbutamol in tissues with typical β2‐adrenoceptors was found to be 8 times more potent than salbutamol in the rabbit jejunum.
5
It is suggested that in the rabbit jejunum ritodrine and salbutamol may act at an atypical β‐adrenoceptor, at which propranolol is a competitive but not very potent antagonist.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2178019</pmid><doi>10.1111/j.1476-5381.1990.tb12083.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Albuterol - pharmacology Animals Biological and medical sciences Cimetidine - pharmacology Female In Vitro Techniques Jejunum - drug effects Male Medical sciences Muscle Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - physiology Norepinephrine - pharmacology Pharmacology. Drug treatments Pyrilamine - pharmacology Rabbits Receptors, Adrenergic, beta - drug effects Receptors, Adrenergic, beta - metabolism Ritodrine - pharmacology Yohimbine - pharmacology |
| title | Evidence that an atypical β‐adrenoceptor mediates the inhibition of spontaneous rhythmical contractions of rabbit isolated jejunum induced by ritodrine and salbutamol |
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