Effects of torbafylline, pentoxifylline and buflomedil on vascularisation and fibre type of rat skeletal muscles subjected to limited blood supply
1 Blood flow (measured by radio‐labelled microspheres), fibre composition and capillary/fibre ratio were estimated in rat fast twitch skeletal muscles (tibialis anterior and extensor digitorum longus) five weeks after unilateral ligation of the common iliac artery in animals treated with either sali...
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| Veröffentlicht in: | British journal of pharmacology 1990-04, Vol.99 (4), p.786-790 |
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| container_title | British journal of pharmacology |
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| creator | Hudlická, Olga Price, Susan |
| description | 1
Blood flow (measured by radio‐labelled microspheres), fibre composition and capillary/fibre ratio were estimated in rat fast twitch skeletal muscles (tibialis anterior and extensor digitorum longus) five weeks after unilateral ligation of the common iliac artery in animals treated with either saline, torbafylline, pentoxifylline or buflomedil.
2
The resting blood flow was lower in muscles with limited blood supply than in their contralateral controls; this difference became statistically insignificant after treatment. Capillary/fibre ratio was similar in all muscles with either intact or limited blood supply and did not change after administration of any of the drugs.
3
The percentage of glycolytic fibres was not changed by ligation, but it decreased significantly in animals treated with torbafylline. This may improve performance in muscles with limited blood supply. |
| doi_str_mv | 10.1111/j.1476-5381.1990.tb13007.x |
| format | Article |
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Blood flow (measured by radio‐labelled microspheres), fibre composition and capillary/fibre ratio were estimated in rat fast twitch skeletal muscles (tibialis anterior and extensor digitorum longus) five weeks after unilateral ligation of the common iliac artery in animals treated with either saline, torbafylline, pentoxifylline or buflomedil.
2
The resting blood flow was lower in muscles with limited blood supply than in their contralateral controls; this difference became statistically insignificant after treatment. Capillary/fibre ratio was similar in all muscles with either intact or limited blood supply and did not change after administration of any of the drugs.
3
The percentage of glycolytic fibres was not changed by ligation, but it decreased significantly in animals treated with torbafylline. This may improve performance in muscles with limited blood supply.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1990.tb13007.x</identifier><identifier>PMID: 2361174</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Body Weight - drug effects ; Capillaries - drug effects ; Cardiovascular system ; In Vitro Techniques ; Male ; Medical sciences ; Muscle Contraction - drug effects ; Muscles - blood supply ; Muscles - drug effects ; Muscles - innervation ; Nerve Fibers - drug effects ; Organ Size - drug effects ; Pentoxifylline - analogs & derivatives ; Pentoxifylline - pharmacology ; Pharmacology. Drug treatments ; Pyrrolidines - pharmacology ; Rats ; Rats, Inbred Strains ; Regional Blood Flow - drug effects ; Theobromine - analogs & derivatives ; Vasodilator agents. Cerebral vasodilators</subject><ispartof>British journal of pharmacology, 1990-04, Vol.99 (4), p.786-790</ispartof><rights>1990 British Pharmacological Society</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4227-acb838967c4699a07571a746a2757d2c2fce97580d9f3a8d73aebe0ee79ff30b3</citedby><cites>FETCH-LOGICAL-c4227-acb838967c4699a07571a746a2757d2c2fce97580d9f3a8d73aebe0ee79ff30b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1917559/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1917559/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6942888$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2361174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hudlická, Olga</creatorcontrib><creatorcontrib>Price, Susan</creatorcontrib><title>Effects of torbafylline, pentoxifylline and buflomedil on vascularisation and fibre type of rat skeletal muscles subjected to limited blood supply</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
Blood flow (measured by radio‐labelled microspheres), fibre composition and capillary/fibre ratio were estimated in rat fast twitch skeletal muscles (tibialis anterior and extensor digitorum longus) five weeks after unilateral ligation of the common iliac artery in animals treated with either saline, torbafylline, pentoxifylline or buflomedil.
2
The resting blood flow was lower in muscles with limited blood supply than in their contralateral controls; this difference became statistically insignificant after treatment. Capillary/fibre ratio was similar in all muscles with either intact or limited blood supply and did not change after administration of any of the drugs.
3
The percentage of glycolytic fibres was not changed by ligation, but it decreased significantly in animals treated with torbafylline. This may improve performance in muscles with limited blood supply.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Body Weight - drug effects</subject><subject>Capillaries - drug effects</subject><subject>Cardiovascular system</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscles - blood supply</subject><subject>Muscles - drug effects</subject><subject>Muscles - innervation</subject><subject>Nerve Fibers - drug effects</subject><subject>Organ Size - drug effects</subject><subject>Pentoxifylline - analogs & derivatives</subject><subject>Pentoxifylline - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrrolidines - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Regional Blood Flow - drug effects</subject><subject>Theobromine - analogs & derivatives</subject><subject>Vasodilator agents. Cerebral vasodilators</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUU1v1DAQtRCoLIWfgGQhxKkJdr5sc0DQqlCkSnCAs-U4Y_DixMFOyuZv8Itx2GgFR3zxzLw3b2b0EHpGSU7Te7nPacWarC45zakQJJ9aWhLC8sM9tDtB99GOpGJGKecP0aMY94QkkNVn6KwoG0pZtUO_ro0BPUXsDZ58aJVZnLMDXOARhskf7JZjNXS4nY3zPXTWYT_gOxX17FSwUU025SvD2DYAnpYRVsGgJhy_g4NJOdzPUTuIOM7tPk2ELs3DzvZ2DVvnfZegcXTLY_TAKBfhyfafoy_vrj9f3WS3H99_uHp7m-mqKFimdMtLLhqmq0YIRVjNqGJVo4oUdYUujAbBak46YUrFO1YqaIEAMGFMSdryHL0-6o5zm47S6d6gnByD7VVYpFdW_osM9pv86u8kFZTVtUgCLzaB4H_MECfZ26jBOTWAn6NkgjdF1TSJ-OpI1MHHGMCchlAiV0flXq62ydU2uToqN0flITU__XvNU-tmYcKfb3jyQzkT1KBtPNEaURWc80R7c6T9tA6W_1hAXn66-ROWvwHCRcN0</recordid><startdate>199004</startdate><enddate>199004</enddate><creator>Hudlická, Olga</creator><creator>Price, Susan</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199004</creationdate><title>Effects of torbafylline, pentoxifylline and buflomedil on vascularisation and fibre type of rat skeletal muscles subjected to limited blood supply</title><author>Hudlická, Olga ; Price, Susan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4227-acb838967c4699a07571a746a2757d2c2fce97580d9f3a8d73aebe0ee79ff30b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Body Weight - drug effects</topic><topic>Capillaries - drug effects</topic><topic>Cardiovascular system</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscles - blood supply</topic><topic>Muscles - drug effects</topic><topic>Muscles - innervation</topic><topic>Nerve Fibers - drug effects</topic><topic>Organ Size - drug effects</topic><topic>Pentoxifylline - analogs & derivatives</topic><topic>Pentoxifylline - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrrolidines - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Regional Blood Flow - drug effects</topic><topic>Theobromine - analogs & derivatives</topic><topic>Vasodilator agents. Cerebral vasodilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hudlická, Olga</creatorcontrib><creatorcontrib>Price, Susan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hudlická, Olga</au><au>Price, Susan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of torbafylline, pentoxifylline and buflomedil on vascularisation and fibre type of rat skeletal muscles subjected to limited blood supply</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1990-04</date><risdate>1990</risdate><volume>99</volume><issue>4</issue><spage>786</spage><epage>790</epage><pages>786-790</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>1
Blood flow (measured by radio‐labelled microspheres), fibre composition and capillary/fibre ratio were estimated in rat fast twitch skeletal muscles (tibialis anterior and extensor digitorum longus) five weeks after unilateral ligation of the common iliac artery in animals treated with either saline, torbafylline, pentoxifylline or buflomedil.
2
The resting blood flow was lower in muscles with limited blood supply than in their contralateral controls; this difference became statistically insignificant after treatment. Capillary/fibre ratio was similar in all muscles with either intact or limited blood supply and did not change after administration of any of the drugs.
3
The percentage of glycolytic fibres was not changed by ligation, but it decreased significantly in animals treated with torbafylline. This may improve performance in muscles with limited blood supply.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2361174</pmid><doi>10.1111/j.1476-5381.1990.tb13007.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0007-1188 1476-5381 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Blood Pressure - drug effects Body Weight - drug effects Capillaries - drug effects Cardiovascular system In Vitro Techniques Male Medical sciences Muscle Contraction - drug effects Muscles - blood supply Muscles - drug effects Muscles - innervation Nerve Fibers - drug effects Organ Size - drug effects Pentoxifylline - analogs & derivatives Pentoxifylline - pharmacology Pharmacology. Drug treatments Pyrrolidines - pharmacology Rats Rats, Inbred Strains Regional Blood Flow - drug effects Theobromine - analogs & derivatives Vasodilator agents. Cerebral vasodilators |
| title | Effects of torbafylline, pentoxifylline and buflomedil on vascularisation and fibre type of rat skeletal muscles subjected to limited blood supply |
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