Effects of morphine on catecholamine release and arrhythmias evoked by myocardial ischaemia in rats
1 The effects of morphine (10 mg kg01 i.p.) on haemodynamics, arrhythmias and plasma and myocardial catecholamines (CA) were studied after coronary artery occlusion in anaesthetized rats. Myocardial intraneuronal CA were assessed histofluorimetrically and CA concentrations measured by high performan...
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| Veröffentlicht in: | British journal of pharmacology 1987-01, Vol.90 (1), p.247-254 |
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| creator | Addicks, Klaus Hirche, Hansjürgen McDonald, Fiona M. Polwin, Wolfgang |
| description | 1
The effects of morphine (10 mg kg01 i.p.) on haemodynamics, arrhythmias and plasma and myocardial catecholamines (CA) were studied after coronary artery occlusion in anaesthetized rats. Myocardial intraneuronal CA were assessed histofluorimetrically and CA concentrations measured by high performance liquid chromatography.
2
Morphine increased blood pressure, presumably due to higher plasma noradrenaline (NA) concentrations found in morphine‐treated rats.
3
Morphine increased the area of catecholamine‐containing fluorescing neurones in the myocardium (as a percentage of total field area) 60 min after sham‐operation (0.87 ± 0.07%) or occlusion (0.57 ± 0.05%) compared to untreated animals (0.67 ± 0.06 and 0.38 ± 0.03% respectively). Tissue NA content was not significantly affected by coronary occlusion and/or morphine within the first 60 min.
4
Morphine had no effect on ischaemia‐induced arrhythmias.
5
Whether the higher intraneuronal NA content following morphine resulted from reduced central sympathetic outflow to the heart, presynaptic inhibition of NA release, or increased uptake due to higher plasma concentrations is unclear. Ischaemia‐induced local NA release appears independent of these mechanisms, as it was unaffected by morphine. |
| doi_str_mv | 10.1111/j.1476-5381.1987.tb16846.x |
| format | Article |
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The effects of morphine (10 mg kg01 i.p.) on haemodynamics, arrhythmias and plasma and myocardial catecholamines (CA) were studied after coronary artery occlusion in anaesthetized rats. Myocardial intraneuronal CA were assessed histofluorimetrically and CA concentrations measured by high performance liquid chromatography.
2
Morphine increased blood pressure, presumably due to higher plasma noradrenaline (NA) concentrations found in morphine‐treated rats.
3
Morphine increased the area of catecholamine‐containing fluorescing neurones in the myocardium (as a percentage of total field area) 60 min after sham‐operation (0.87 ± 0.07%) or occlusion (0.57 ± 0.05%) compared to untreated animals (0.67 ± 0.06 and 0.38 ± 0.03% respectively). Tissue NA content was not significantly affected by coronary occlusion and/or morphine within the first 60 min.
4
Morphine had no effect on ischaemia‐induced arrhythmias.
5
Whether the higher intraneuronal NA content following morphine resulted from reduced central sympathetic outflow to the heart, presynaptic inhibition of NA release, or increased uptake due to higher plasma concentrations is unclear. Ischaemia‐induced local NA release appears independent of these mechanisms, as it was unaffected by morphine.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1987.tb16846.x</identifier><identifier>PMID: 3814921</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Analgesics ; Animals ; Arrhythmias, Cardiac - etiology ; Arrhythmias, Cardiac - physiopathology ; Biological and medical sciences ; Catecholamines - metabolism ; Coronary Disease - complications ; Coronary Disease - metabolism ; Fluorescence ; Hemodynamics - drug effects ; Male ; Medical sciences ; Morphine - pharmacology ; Myocardium - metabolism ; Neuropharmacology ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains</subject><ispartof>British journal of pharmacology, 1987-01, Vol.90 (1), p.247-254</ispartof><rights>1987 British Pharmacological Society</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4536-7c4be33bb7676fe499cef043406aa9c11421c1fcf19dca487b075a7c85dd34ae3</citedby><cites>FETCH-LOGICAL-c4536-7c4be33bb7676fe499cef043406aa9c11421c1fcf19dca487b075a7c85dd34ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1917263/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1917263/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7400244$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3814921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Addicks, Klaus</creatorcontrib><creatorcontrib>Hirche, Hansjürgen</creatorcontrib><creatorcontrib>McDonald, Fiona M.</creatorcontrib><creatorcontrib>Polwin, Wolfgang</creatorcontrib><title>Effects of morphine on catecholamine release and arrhythmias evoked by myocardial ischaemia in rats</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
The effects of morphine (10 mg kg01 i.p.) on haemodynamics, arrhythmias and plasma and myocardial catecholamines (CA) were studied after coronary artery occlusion in anaesthetized rats. Myocardial intraneuronal CA were assessed histofluorimetrically and CA concentrations measured by high performance liquid chromatography.
2
Morphine increased blood pressure, presumably due to higher plasma noradrenaline (NA) concentrations found in morphine‐treated rats.
3
Morphine increased the area of catecholamine‐containing fluorescing neurones in the myocardium (as a percentage of total field area) 60 min after sham‐operation (0.87 ± 0.07%) or occlusion (0.57 ± 0.05%) compared to untreated animals (0.67 ± 0.06 and 0.38 ± 0.03% respectively). Tissue NA content was not significantly affected by coronary occlusion and/or morphine within the first 60 min.
4
Morphine had no effect on ischaemia‐induced arrhythmias.
5
Whether the higher intraneuronal NA content following morphine resulted from reduced central sympathetic outflow to the heart, presynaptic inhibition of NA release, or increased uptake due to higher plasma concentrations is unclear. Ischaemia‐induced local NA release appears independent of these mechanisms, as it was unaffected by morphine.</description><subject>Analgesics</subject><subject>Animals</subject><subject>Arrhythmias, Cardiac - etiology</subject><subject>Arrhythmias, Cardiac - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Catecholamines - metabolism</subject><subject>Coronary Disease - complications</subject><subject>Coronary Disease - metabolism</subject><subject>Fluorescence</subject><subject>Hemodynamics - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Morphine - pharmacology</subject><subject>Myocardium - metabolism</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkV-L1DAUxYMo67j6EYQg4ltr0mSS1gdRl_0jLOiDPofb9MZmbJsx6azbb2_rlEGfxLwk3N-5h3tzCHnBWc7n83qXc6lVthUlz3lV6nysuSqlyu8fkM0JPSQbxpjOOC_Lx-RJSjvGZqi3Z-RsxrIq-IbYS-fQjokGR_sQ960fkIaBWhjRtqGDfilE7BASUhgaCjG209j2HhLFu_AdG1pPtJ-Chdh46KhPtgWcOfUDjTCmp-SRgy7hs_U-J1-vLr9c3GS3n64_Xry_zazcCpVpK2sUoq610sqhrCqLjkkhmQKoLOey4JY763jVWJClrpnegrbltmmEBBTn5O3Rd3-oe2wsDmOEzuyj7yFOJoA3f5PBt-ZbuDO84rpQYjZ4tRrE8OOAaTT9vAx2HQwYDsloLbTWSv5TOH8zU4WuZuGbo9DGkFJEd5qGM7NkaXaLWJklMLNkadYszf3c_PzPfU6ta3gzf7lySBY6F2GwPp1kWjJWyGXYd0fZT9_h9B8DmA-fb34_xS-6fb7j</recordid><startdate>198701</startdate><enddate>198701</enddate><creator>Addicks, Klaus</creator><creator>Hirche, Hansjürgen</creator><creator>McDonald, Fiona M.</creator><creator>Polwin, Wolfgang</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>198701</creationdate><title>Effects of morphine on catecholamine release and arrhythmias evoked by myocardial ischaemia in rats</title><author>Addicks, Klaus ; Hirche, Hansjürgen ; McDonald, Fiona M. ; Polwin, Wolfgang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4536-7c4be33bb7676fe499cef043406aa9c11421c1fcf19dca487b075a7c85dd34ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Analgesics</topic><topic>Animals</topic><topic>Arrhythmias, Cardiac - etiology</topic><topic>Arrhythmias, Cardiac - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Catecholamines - metabolism</topic><topic>Coronary Disease - complications</topic><topic>Coronary Disease - metabolism</topic><topic>Fluorescence</topic><topic>Hemodynamics - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Morphine - pharmacology</topic><topic>Myocardium - metabolism</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Addicks, Klaus</creatorcontrib><creatorcontrib>Hirche, Hansjürgen</creatorcontrib><creatorcontrib>McDonald, Fiona M.</creatorcontrib><creatorcontrib>Polwin, Wolfgang</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Addicks, Klaus</au><au>Hirche, Hansjürgen</au><au>McDonald, Fiona M.</au><au>Polwin, Wolfgang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of morphine on catecholamine release and arrhythmias evoked by myocardial ischaemia in rats</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1987-01</date><risdate>1987</risdate><volume>90</volume><issue>1</issue><spage>247</spage><epage>254</epage><pages>247-254</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>1
The effects of morphine (10 mg kg01 i.p.) on haemodynamics, arrhythmias and plasma and myocardial catecholamines (CA) were studied after coronary artery occlusion in anaesthetized rats. Myocardial intraneuronal CA were assessed histofluorimetrically and CA concentrations measured by high performance liquid chromatography.
2
Morphine increased blood pressure, presumably due to higher plasma noradrenaline (NA) concentrations found in morphine‐treated rats.
3
Morphine increased the area of catecholamine‐containing fluorescing neurones in the myocardium (as a percentage of total field area) 60 min after sham‐operation (0.87 ± 0.07%) or occlusion (0.57 ± 0.05%) compared to untreated animals (0.67 ± 0.06 and 0.38 ± 0.03% respectively). Tissue NA content was not significantly affected by coronary occlusion and/or morphine within the first 60 min.
4
Morphine had no effect on ischaemia‐induced arrhythmias.
5
Whether the higher intraneuronal NA content following morphine resulted from reduced central sympathetic outflow to the heart, presynaptic inhibition of NA release, or increased uptake due to higher plasma concentrations is unclear. Ischaemia‐induced local NA release appears independent of these mechanisms, as it was unaffected by morphine.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3814921</pmid><doi>10.1111/j.1476-5381.1987.tb16846.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analgesics Animals Arrhythmias, Cardiac - etiology Arrhythmias, Cardiac - physiopathology Biological and medical sciences Catecholamines - metabolism Coronary Disease - complications Coronary Disease - metabolism Fluorescence Hemodynamics - drug effects Male Medical sciences Morphine - pharmacology Myocardium - metabolism Neuropharmacology Pharmacology. Drug treatments Rats Rats, Inbred Strains |
| title | Effects of morphine on catecholamine release and arrhythmias evoked by myocardial ischaemia in rats |
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