Calcium channel inhibitors suppress the morphine‐withdrawal syndrome in rats

1 The effects of the Ca2+‐channel blockers verapamil and nimodipine, on the behavioural signs of naloxone (1 mg kg−1)‐induced abstinence syndrome in morphine‐dependent rats, were evaluated. The content of noradrenaline (NA) and of its metabolite 3‐methoxy‐4‐hydroxyphenylglycol (MHPG) was measured, u...

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Veröffentlicht in:	British journal of pharmacology 1986-07, Vol.88 (3), p.561-567
Hauptverfasser:	Bongianni, F., Carla', V., Moroni, F., Pellegrini‐Giampietro, D.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Biological and medical sciences Brain Chemistry - drug effects Calcium Channel Blockers - pharmacology Drug addictions Medical sciences Methoxyhydroxyphenylglycol - metabolism Morphine - adverse effects Morphine Dependence - metabolism Naloxone - antagonists & inhibitors Nicotinic Acids - pharmacology Nimodipine Norepinephrine - metabolism Rats Receptors, Opioid - drug effects Substance Withdrawal Syndrome - metabolism Substance Withdrawal Syndrome - prevention & control Toxicology Verapamil - pharmacology
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