Pulmonary surfactant as vehicle for intratracheally instilled tobramycin in mice infected with Klebsiella pneumoniae

1 The use of pulmonary surfactant has been proposed as a vehicle for antibiotic delivery to the alveolar compartment of the lung. This study investigated survival rates of mice with a respiratory Klebsiella pneumoniae infection treated intratracheally with tobramycin using a natural exogenous surfac...

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Veröffentlicht in:	British journal of pharmacology 1996-11, Vol.119 (6), p.1145-1148
Hauptverfasser:	Veen, Annemarie van't, Mouton, Johan W., Gommers, Diederik, Lachmann, Burkhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage antibiotics bacterial pneumonia drug carrier Klebsiella Infections - drug therapy Klebsiella pneumoniae Male Mice Pharmaceutical Vehicles Pulmonary surfactant Pulmonary Surfactants - administration & dosage tobramycin Tobramycin - administration & dosage tracheal instillation
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