M1 and M3 muscarinic receptors in human pulmonary arteries

1 Acetylcholine (ACh) and the M1 agonists (McN‐A‐343 or PD142505) relaxed human isolated pulmonary arteries which were pre‐contracted with noradrenaline (10 μm). In preparations where the endothelium had been removed ACh induced a contractile response whereas the M1 agonists (McN‐A‐343 or PD142505)...

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Veröffentlicht in:	British journal of pharmacology 1996-09, Vol.119 (1), p.149-157
Hauptverfasser:	Norel, X., Walch, L., Costantino, M., Labat, C., Gorenne, I., Dulmet, E., Rossi, F., Brink, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine Acetylcholine - pharmacology atropine Biological and medical sciences Blood vessels and receptors Cholinergic Agonists - pharmacology Cyclooxygenase Inhibitors - pharmacology Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Human pulmonary arteries Humans In Vitro Techniques McN‐A‐343 methoctramine Muscarinic Agonists - pharmacology muscarinic receptor Muscle Contraction - drug effects Muscle Relaxation - drug effects Muscle, Smooth - drug effects Muscle, Smooth - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - physiology PD142505 pFHHSiD phenoxybenzamine Phenoxybenzamine - pharmacology pirenzepine Pirenzepine - pharmacology Prostaglandin-Endoperoxide Synthases - physiology Pulmonary Artery - drug effects Pulmonary Artery - metabolism Receptor, Muscarinic M1 Receptor, Muscarinic M3 Receptors, Muscarinic - metabolism Vertebrates: cardiovascular system
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