Haplotype and phenotype analysis of six recurrent BRCA1 mutations in 61 families : Results of an international study

Several BRCA1 mutations have now been found to occur in geographically diverse breast and ovarian cancer families. To investigate mutation origin and mutation-specific phenotypes due to BRCA1, we constructed a haplotype of nine polymorphic markers within or immediately flanking the BRCA1 locus in a...

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Veröffentlicht in:	American journal of human genetics 1996-02, Vol.58 (2), p.271-280
Hauptverfasser:	NEUHAUSEN, S. L, MAZOYER, S, SOLOMON, E, WEBER, B, COUCH, F, STRUEWING, J, TONIN, P, DUROCHER, F, NAROD, S, SKOLNICK, M. H, LENOIR, G, SEROVA, O, FRIEDMAN, L, PONDER, B, STOPPA-LYONNET, D, EASTON, D, KING, M.-C, GOLDGAR, D. E, STRATTON, M, OFFIT, K, CALIGO, A, TOMLINSON, G, CANNON-ALBRIGHT, L, BISHOP, T, KELSELL, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biological and medical sciences BRCA1 Protein Breast Neoplasms - genetics Chromosome Mapping Family Health Female Female genital diseases Genetic Markers - genetics Genotype Gynecology. Andrology. Obstetrics Haplotypes - genetics Humans Medical sciences Mutation Neoplasm Proteins - genetics Ovarian Neoplasms - genetics Phenotype Polymorphism, Single-Stranded Conformational Transcription Factors - genetics Tumors
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