Establishing the robustness of short-tandem-repeat statistics for forensic applications
Before the introduction of a four-locus multiplex short-tandem-repeat (STR) system into casework, an extensive series of tests were carried out to determine robust procedures for assessing the evidential value of a match between crime and suspect samples. Twelve databases were analyzed from the thre...
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| Veröffentlicht in: | American journal of human genetics 1996-02, Vol.58 (2), p.398-407 |
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| container_title | American journal of human genetics |
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| creator | EVETT, I. W GILL, P. D SCRANAGE, J. K WEIR, B. S |
| description | Before the introduction of a four-locus multiplex short-tandem-repeat (STR) system into casework, an extensive series of tests were carried out to determine robust procedures for assessing the evidential value of a match between crime and suspect samples. Twelve databases were analyzed from the three main ethnic groups encountered in casework in the United Kingdom: Caucasians, Afro-Caribbeans, and Asians from the Indian subcontinent. Independence tests resulted in a number of significant results, and the impact that these might have on forensic casework was investigated. It is demonstrated that previously published methods provide a simple procedure for correcting allele frequencies--and that this leads to conservative casework estimates of evidential value. |
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It is demonstrated that previously published methods provide a simple procedure for correcting allele frequencies--and that this leads to conservative casework estimates of evidential value.</description><subject>African Continental Ancestry Group - genetics</subject><subject>Alleles</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biological and medical sciences</subject><subject>Databases, Factual</subject><subject>DNA Fingerprinting - methods</subject><subject>DNA Primers - genetics</subject><subject>Ethnic Groups - genetics</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Fluorescence</subject><subject>Forensic medicine</subject><subject>Forensic Medicine - methods</subject><subject>Genetic Heterogeneity</subject><subject>Genetic Markers - genetics</subject><subject>Genotype</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Likelihood Functions</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Public health. 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S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Establishing the robustness of short-tandem-repeat statistics for forensic applications</atitle><jtitle>American journal of human genetics</jtitle><addtitle>Am J Hum Genet</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>58</volume><issue>2</issue><spage>398</spage><epage>407</epage><pages>398-407</pages><issn>0002-9297</issn><eissn>1537-6605</eissn><coden>AJHGAG</coden><abstract>Before the introduction of a four-locus multiplex short-tandem-repeat (STR) system into casework, an extensive series of tests were carried out to determine robust procedures for assessing the evidential value of a match between crime and suspect samples. Twelve databases were analyzed from the three main ethnic groups encountered in casework in the United Kingdom: Caucasians, Afro-Caribbeans, and Asians from the Indian subcontinent. Independence tests resulted in a number of significant results, and the impact that these might have on forensic casework was investigated. It is demonstrated that previously published methods provide a simple procedure for correcting allele frequencies--and that this leads to conservative casework estimates of evidential value.</abstract><cop>Chicago, IL</cop><pub>University of Chicago Press</pub><pmid>8571967</pmid><tpages>10</tpages></addata></record> |
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| ispartof | American journal of human genetics, 1996-02, Vol.58 (2), p.398-407 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | African Continental Ancestry Group - genetics Alleles Asian Continental Ancestry Group - genetics Biological and medical sciences Databases, Factual DNA Fingerprinting - methods DNA Primers - genetics Ethnic Groups - genetics European Continental Ancestry Group - genetics Fluorescence Forensic medicine Forensic Medicine - methods Genetic Heterogeneity Genetic Markers - genetics Genotype Heterozygote Humans Likelihood Functions Medical sciences Miscellaneous Public health. Hygiene Public health. Hygiene-occupational medicine Repetitive Sequences, Nucleic Acid - genetics |
| title | Establishing the robustness of short-tandem-repeat statistics for forensic applications |
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