Substrate Chemistry-Dependent Conformations of Single Laminin Molecules on Polymer Surfaces are Revealed by the Phase Signal of Atomic Force Microscopy

The conformation of single laminin molecules adsorbed on synthetic substrates is directly observed making use of the phase magnitude in tapping mode atomic force microscopy (AFM). With AFM, it is not possible to differentiate the proteins on the substrate if use is made of the height signal, since t...

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Veröffentlicht in:	Biophysical journal 2007-07, Vol.93 (1), p.202-207
Hauptverfasser:	Hernández, Jose Carlos Rodríguez, Salmerón Sánchez, Manuel, Soria, José Miguel, Gómez Ribelles, José Luis, Monleón Pradas, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biochemistry Cell adhesion & migration Laminin - chemistry Laminin - ultrastructure Microscopy Microscopy, Atomic Force - methods Polymers Polymers - chemistry Protein Binding Protein Conformation Proteins Surface Properties
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