The inhibition of granuloma formation around Schistosoma mansoni eggs
The effect of protein, calorie, and vitamin deficiency states on the granulomatous response of mice to eggs of S mansoni injected into the microvasculature of the lungs was studied. Moderate to severe protein and calorie deficiencies, as well as thiamine and vitamin C deficiencies, inhibited the hos...
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| Veröffentlicht in: | The American journal of pathology 1975-06, Vol.79 (3), p.435-452 |
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| creator | Akpom, CA Warren, KS |
| description | The effect of protein, calorie, and vitamin deficiency states on the granulomatous response of mice to eggs of S mansoni injected into the microvasculature of the lungs was studied. Moderate to severe protein and calorie deficiencies, as well as thiamine and vitamin C deficiencies, inhibited the host's granulomatous response to S mansoni eggs, which is a form of delayed-type hypersensitivity. The antivitamins neopyrithiamine hydrochloride and desoxypyridoxine hydrochloride were both highly effective in suppressing granuloma formation, but the former proved highly toxic at the doses utilized. Desoxypyridoxine hydrochloride given at a dose of .05 mg/mouse/day produced almost complete inhibition of granuloma formation; marked suppression was also present at fivefold dilution. This antivitamin appearts to be one of the most powerful immunosuppressive measures so far examined. |
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Moderate to severe protein and calorie deficiencies, as well as thiamine and vitamin C deficiencies, inhibited the host's granulomatous response to S mansoni eggs, which is a form of delayed-type hypersensitivity. The antivitamins neopyrithiamine hydrochloride and desoxypyridoxine hydrochloride were both highly effective in suppressing granuloma formation, but the former proved highly toxic at the doses utilized. Desoxypyridoxine hydrochloride given at a dose of .05 mg/mouse/day produced almost complete inhibition of granuloma formation; marked suppression was also present at fivefold dilution. This antivitamin appearts to be one of the most powerful immunosuppressive measures so far examined.</description><identifier>ISSN: 0002-9440</identifier><identifier>EISSN: 1525-2191</identifier><identifier>PMID: 806231</identifier><language>eng</language><publisher>United States: ASIP</publisher><subject>Animals ; Ascorbic Acid Deficiency - immunology ; Avitaminosis - immunology ; Body Weight ; Diet, Reducing ; Female ; Granuloma - etiology ; Granuloma - immunology ; Immunity, Cellular ; Immunosuppression ; Macrophages - immunology ; Mice ; Ovum - immunology ; Protein Deficiency - immunology ; Protein-Energy Malnutrition - immunology ; Pyridinium Compounds - pharmacology ; Pyridinium Compounds - toxicity ; Pyridoxine - administration & dosage ; Pyridoxine - analogs & derivatives ; Pyridoxine - pharmacology ; Pyrimidines - pharmacology ; Pyrimidines - toxicity ; Schistosoma mansoni - immunology ; Thiamine Deficiency - immunology</subject><ispartof>The American journal of pathology, 1975-06, Vol.79 (3), p.435-452</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913016/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913016/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/806231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akpom, CA</creatorcontrib><creatorcontrib>Warren, KS</creatorcontrib><title>The inhibition of granuloma formation around Schistosoma mansoni eggs</title><title>The American journal of pathology</title><addtitle>Am J Pathol</addtitle><description>The effect of protein, calorie, and vitamin deficiency states on the granulomatous response of mice to eggs of S mansoni injected into the microvasculature of the lungs was studied. Moderate to severe protein and calorie deficiencies, as well as thiamine and vitamin C deficiencies, inhibited the host's granulomatous response to S mansoni eggs, which is a form of delayed-type hypersensitivity. The antivitamins neopyrithiamine hydrochloride and desoxypyridoxine hydrochloride were both highly effective in suppressing granuloma formation, but the former proved highly toxic at the doses utilized. Desoxypyridoxine hydrochloride given at a dose of .05 mg/mouse/day produced almost complete inhibition of granuloma formation; marked suppression was also present at fivefold dilution. This antivitamin appearts to be one of the most powerful immunosuppressive measures so far examined.</description><subject>Animals</subject><subject>Ascorbic Acid Deficiency - immunology</subject><subject>Avitaminosis - immunology</subject><subject>Body Weight</subject><subject>Diet, Reducing</subject><subject>Female</subject><subject>Granuloma - etiology</subject><subject>Granuloma - immunology</subject><subject>Immunity, Cellular</subject><subject>Immunosuppression</subject><subject>Macrophages - immunology</subject><subject>Mice</subject><subject>Ovum - immunology</subject><subject>Protein Deficiency - immunology</subject><subject>Protein-Energy Malnutrition - immunology</subject><subject>Pyridinium Compounds - pharmacology</subject><subject>Pyridinium Compounds - toxicity</subject><subject>Pyridoxine - administration & dosage</subject><subject>Pyridoxine - analogs & derivatives</subject><subject>Pyridoxine - pharmacology</subject><subject>Pyrimidines - pharmacology</subject><subject>Pyrimidines - toxicity</subject><subject>Schistosoma mansoni - immunology</subject><subject>Thiamine Deficiency - immunology</subject><issn>0002-9440</issn><issn>1525-2191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtOwzAQRS3EqxT-gEU2LCP5GTsbJFSVh1SJBWVtTR0ndpXYlZ2C-HsCRQhWo5lz5yzuEZoRQUVJSU2O0QxjTMuac3yOLnLeTmvFFD5DpwpXlJEZWq6dLXxwfuNHH0MR26JLEPZ9HKBoYxrg-wwp7kNTvBjn8xjzFxwg5Bh8YbsuX6KTFvpsr37mHL3eL9eLx3L1_PC0uFuVjjBZlY2krGJCqgYEUVxJJSRWAFQZxVTLmoZWUgqmiMGSc2vqmsEGm5ZybhQ2bI5uD97dfjPYxtgwJuj1LvkB0oeO4PV_ErzTXXzTUxsMk2oSXP8V_H4e6pjwzQE737l3n6zOA_T9FCYatjtZa6Y5E-wTiQdqSg</recordid><startdate>19750601</startdate><enddate>19750601</enddate><creator>Akpom, CA</creator><creator>Warren, KS</creator><general>ASIP</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>19750601</creationdate><title>The inhibition of granuloma formation around Schistosoma mansoni eggs</title><author>Akpom, CA ; Warren, KS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h1376-d72363578da51848785708aa28c838f3dd26775381c0744ec993ab0cf244c80c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Ascorbic Acid Deficiency - immunology</topic><topic>Avitaminosis - immunology</topic><topic>Body Weight</topic><topic>Diet, Reducing</topic><topic>Female</topic><topic>Granuloma - etiology</topic><topic>Granuloma - immunology</topic><topic>Immunity, Cellular</topic><topic>Immunosuppression</topic><topic>Macrophages - immunology</topic><topic>Mice</topic><topic>Ovum - immunology</topic><topic>Protein Deficiency - immunology</topic><topic>Protein-Energy Malnutrition - immunology</topic><topic>Pyridinium Compounds - pharmacology</topic><topic>Pyridinium Compounds - toxicity</topic><topic>Pyridoxine - administration & dosage</topic><topic>Pyridoxine - analogs & derivatives</topic><topic>Pyridoxine - pharmacology</topic><topic>Pyrimidines - pharmacology</topic><topic>Pyrimidines - toxicity</topic><topic>Schistosoma mansoni - immunology</topic><topic>Thiamine Deficiency - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akpom, CA</creatorcontrib><creatorcontrib>Warren, KS</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akpom, CA</au><au>Warren, KS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The inhibition of granuloma formation around Schistosoma mansoni eggs</atitle><jtitle>The American journal of pathology</jtitle><addtitle>Am J Pathol</addtitle><date>1975-06-01</date><risdate>1975</risdate><volume>79</volume><issue>3</issue><spage>435</spage><epage>452</epage><pages>435-452</pages><issn>0002-9440</issn><eissn>1525-2191</eissn><abstract>The effect of protein, calorie, and vitamin deficiency states on the granulomatous response of mice to eggs of S mansoni injected into the microvasculature of the lungs was studied. Moderate to severe protein and calorie deficiencies, as well as thiamine and vitamin C deficiencies, inhibited the host's granulomatous response to S mansoni eggs, which is a form of delayed-type hypersensitivity. The antivitamins neopyrithiamine hydrochloride and desoxypyridoxine hydrochloride were both highly effective in suppressing granuloma formation, but the former proved highly toxic at the doses utilized. Desoxypyridoxine hydrochloride given at a dose of .05 mg/mouse/day produced almost complete inhibition of granuloma formation; marked suppression was also present at fivefold dilution. This antivitamin appearts to be one of the most powerful immunosuppressive measures so far examined.</abstract><cop>United States</cop><pub>ASIP</pub><pmid>806231</pmid><tpages>18</tpages></addata></record> |
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| ispartof | The American journal of pathology, 1975-06, Vol.79 (3), p.435-452 |
| issn | 0002-9440 1525-2191 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Ascorbic Acid Deficiency - immunology Avitaminosis - immunology Body Weight Diet, Reducing Female Granuloma - etiology Granuloma - immunology Immunity, Cellular Immunosuppression Macrophages - immunology Mice Ovum - immunology Protein Deficiency - immunology Protein-Energy Malnutrition - immunology Pyridinium Compounds - pharmacology Pyridinium Compounds - toxicity Pyridoxine - administration & dosage Pyridoxine - analogs & derivatives Pyridoxine - pharmacology Pyrimidines - pharmacology Pyrimidines - toxicity Schistosoma mansoni - immunology Thiamine Deficiency - immunology |
| title | The inhibition of granuloma formation around Schistosoma mansoni eggs |
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