Significance of Rh-sensitization during Pregnancy: Its Relation to a Preventive Programme
A study of the incidence of Rh-sensitization showed a 6.5% incidence of anti-D appearing for the first time during the last trimester of pregnancy. In 24 of the 29 subjects these antibodies were weak, and were found only when a sensitive technique using enzyme-treated Rh-deletion test cells was empl...
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| Veröffentlicht in: | BMJ 1968-11, Vol.4 (5629), p.479-482 |
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| creator | Godel, John C. Buchanan, Donald I. Jarosch, Jean M. McHugh, Maureen |
| description | A study of the incidence of Rh-sensitization showed a 6.5% incidence of anti-D appearing for the first time during the last trimester of pregnancy. In 24 of the 29 subjects these antibodies were weak, and were found only when a sensitive technique using enzyme-treated Rh-deletion test cells was employed. The remaining five, however, had high-titre antibodies, which were associated with a positive Coombs test on cord blood. Rh-immune globulin administered at delivery resulted in disappearance of the anti-D in all but one of the subjects with weak antibody to whom it was given, suggesting that this treatment can reverse early sensitization. There was no effect when Rh-immune globulin was given to one subject with a high anti-D titre. Since sensitization has been found to occur frequently during the last trimester of pregnancy, an antenatal schedule of prophylaxis is advocated. |
| doi_str_mv | 10.1136/bmj.4.5629.479 |
| format | Article |
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In 24 of the 29 subjects these antibodies were weak, and were found only when a sensitive technique using enzyme-treated Rh-deletion test cells was employed. The remaining five, however, had high-titre antibodies, which were associated with a positive Coombs test on cord blood. Rh-immune globulin administered at delivery resulted in disappearance of the anti-D in all but one of the subjects with weak antibody to whom it was given, suggesting that this treatment can reverse early sensitization. There was no effect when Rh-immune globulin was given to one subject with a high anti-D titre. Since sensitization has been found to occur frequently during the last trimester of pregnancy, an antenatal schedule of prophylaxis is advocated.</description><identifier>ISSN: 0007-1447</identifier><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1468-5833</identifier><identifier>DOI: 10.1136/bmj.4.5629.479</identifier><identifier>PMID: 4177135</identifier><language>eng</language><publisher>England: British Medical Journal Publishing Group</publisher><subject>Antibodies ; Antibody Formation ; Antigens ; Blood grouping ; Coombs Test ; Delivery, Obstetric ; Erythroblastosis, Fetal - prevention & control ; Female ; Follow-Up Studies ; gamma-Globulins - administration & dosage ; Globulins ; Humans ; Infants ; Papers and Originals ; Parity ; Pregnancy ; Pregnancy Complications, Hematologic ; Rh-Hr Blood-Group System ; Sensitization ; Trimesters of pregnancy</subject><ispartof>BMJ, 1968-11, Vol.4 (5629), p.479-482</ispartof><rights>Copyright 1968 British Medical Journal</rights><rights>Copyright BMJ Publishing Group LTD Nov 23, 1968</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b507t-2a61165672ba2160e20cae2a96e0e9428ca6d833dba7d888d588e0fe0a76c5bd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/20394837$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/20394837$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,724,777,781,800,882,27905,27906,53772,53774,57998,58231</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4177135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Godel, John C.</creatorcontrib><creatorcontrib>Buchanan, Donald I.</creatorcontrib><creatorcontrib>Jarosch, Jean M.</creatorcontrib><creatorcontrib>McHugh, Maureen</creatorcontrib><title>Significance of Rh-sensitization during Pregnancy: Its Relation to a Preventive Programme</title><title>BMJ</title><addtitle>Br Med J</addtitle><description>A study of the incidence of Rh-sensitization showed a 6.5% incidence of anti-D appearing for the first time during the last trimester of pregnancy. In 24 of the 29 subjects these antibodies were weak, and were found only when a sensitive technique using enzyme-treated Rh-deletion test cells was employed. The remaining five, however, had high-titre antibodies, which were associated with a positive Coombs test on cord blood. Rh-immune globulin administered at delivery resulted in disappearance of the anti-D in all but one of the subjects with weak antibody to whom it was given, suggesting that this treatment can reverse early sensitization. There was no effect when Rh-immune globulin was given to one subject with a high anti-D titre. Since sensitization has been found to occur frequently during the last trimester of pregnancy, an antenatal schedule of prophylaxis is advocated.</description><subject>Antibodies</subject><subject>Antibody Formation</subject><subject>Antigens</subject><subject>Blood grouping</subject><subject>Coombs Test</subject><subject>Delivery, Obstetric</subject><subject>Erythroblastosis, Fetal - prevention & control</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>gamma-Globulins - administration & dosage</subject><subject>Globulins</subject><subject>Humans</subject><subject>Infants</subject><subject>Papers and Originals</subject><subject>Parity</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Hematologic</subject><subject>Rh-Hr Blood-Group System</subject><subject>Sensitization</subject><subject>Trimesters of pregnancy</subject><issn>0007-1447</issn><issn>0959-8138</issn><issn>1468-5833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkVuL1DAYhoMo67DurXdCQRC8aM05qReCO54Wh1XGE16FtE27GdtkTdrB9deb0mE83HjVlOfJx_vlBeA-ggVChD-phl1BC8ZxWVBR3gIrRLnMmSTkNlhBCEWOKBV3wVmMu_SLiZAlpyfghCIhEGEr8PWD7Zxtba1dbTLfZturPBoX7Wh_6tF6lzVTsK7L3gfTuSTdPM0uxphtTb_g0Wd6hnvjRrs36ei7oIfB3AN3Wt1Hc3b4noJPr15-XL_JN-9eX6yfb_KKQTHmWHOEOOMCVxojDg2GtTZYl9xAU1Isa82btFBTadFIKRsmpYGtgVrwmlUNOQXPlrnXUzWYpk45gu7VdbCDDjfKa6v-Js5eqc7vFSoRFpCnAY8OA4L_Ppk4qsHG2vS9dsZPUUkGCWSYJfHhP-LOT8Gl5VR6To4g52i2isWqg48xmPYYBUE1t6ZSa4qquTWVWksXHvy5wFE_dPSb7-LowxFjSEoqiUg8X7iNo_lx5Dp8U1wQwdTl57U6v9ycf3kBt-pt8h8v_pzjP9l-ARSkubQ</recordid><startdate>19681123</startdate><enddate>19681123</enddate><creator>Godel, John C.</creator><creator>Buchanan, Donald I.</creator><creator>Jarosch, Jean M.</creator><creator>McHugh, Maureen</creator><general>British Medical Journal Publishing Group</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19681123</creationdate><title>Significance of Rh-sensitization during Pregnancy: Its Relation to a Preventive Programme</title><author>Godel, John C. ; Buchanan, Donald I. ; Jarosch, Jean M. ; McHugh, Maureen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b507t-2a61165672ba2160e20cae2a96e0e9428ca6d833dba7d888d588e0fe0a76c5bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Antibodies</topic><topic>Antibody Formation</topic><topic>Antigens</topic><topic>Blood grouping</topic><topic>Coombs Test</topic><topic>Delivery, Obstetric</topic><topic>Erythroblastosis, Fetal - prevention & control</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>gamma-Globulins - administration & dosage</topic><topic>Globulins</topic><topic>Humans</topic><topic>Infants</topic><topic>Papers and Originals</topic><topic>Parity</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Hematologic</topic><topic>Rh-Hr Blood-Group System</topic><topic>Sensitization</topic><topic>Trimesters of pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Godel, John C.</creatorcontrib><creatorcontrib>Buchanan, Donald I.</creatorcontrib><creatorcontrib>Jarosch, Jean M.</creatorcontrib><creatorcontrib>McHugh, Maureen</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Godel, John C.</au><au>Buchanan, Donald I.</au><au>Jarosch, Jean M.</au><au>McHugh, Maureen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of Rh-sensitization during Pregnancy: Its Relation to a Preventive Programme</atitle><jtitle>BMJ</jtitle><addtitle>Br Med J</addtitle><date>1968-11-23</date><risdate>1968</risdate><volume>4</volume><issue>5629</issue><spage>479</spage><epage>482</epage><pages>479-482</pages><issn>0007-1447</issn><issn>0959-8138</issn><eissn>1468-5833</eissn><abstract>A study of the incidence of Rh-sensitization showed a 6.5% incidence of anti-D appearing for the first time during the last trimester of pregnancy. In 24 of the 29 subjects these antibodies were weak, and were found only when a sensitive technique using enzyme-treated Rh-deletion test cells was employed. The remaining five, however, had high-titre antibodies, which were associated with a positive Coombs test on cord blood. Rh-immune globulin administered at delivery resulted in disappearance of the anti-D in all but one of the subjects with weak antibody to whom it was given, suggesting that this treatment can reverse early sensitization. There was no effect when Rh-immune globulin was given to one subject with a high anti-D titre. Since sensitization has been found to occur frequently during the last trimester of pregnancy, an antenatal schedule of prophylaxis is advocated.</abstract><cop>England</cop><pub>British Medical Journal Publishing Group</pub><pmid>4177135</pmid><doi>10.1136/bmj.4.5629.479</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMJ, 1968-11, Vol.4 (5629), p.479-482 |
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| source | MEDLINE; Jstor Complete Legacy; PubMed Central |
| subjects | Antibodies Antibody Formation Antigens Blood grouping Coombs Test Delivery, Obstetric Erythroblastosis, Fetal - prevention & control Female Follow-Up Studies gamma-Globulins - administration & dosage Globulins Humans Infants Papers and Originals Parity Pregnancy Pregnancy Complications, Hematologic Rh-Hr Blood-Group System Sensitization Trimesters of pregnancy |
| title | Significance of Rh-sensitization during Pregnancy: Its Relation to a Preventive Programme |
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