Stimulation of chloride secretion by P1 purinoceptor agonists in cystic fibrosis phenotype airway epithelial cell line CFPEo

1 P1 purinoceptor agonists like adenosine have been shown to stimulate Cl−1 transport in secretory epithelia. In the present study, we investigated whether P1 agonist‐induced Cl−1 secretion is preserved in cystic fibrosis airway epithelium and which signalling mechanism is involved. The effects of p...

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Veröffentlicht in:	British journal of pharmacology 1994-05, Vol.112 (1), p.169-175
Hauptverfasser:	Chao, Anthony C., Zifferblatt, Jonathan B., Wagner, John A., Dong, Y.‐J., Gruenert, Dieter C., Gardner, Phyllis
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Nucleotides - pharmacology Adenosine - analogs & derivatives Adenosine - pharmacology airway epithelium Ca2 Calcium - metabolism Cell Line chloride channel Chloride Channels - drug effects Chloride Channels - metabolism Chlorides - metabolism cystic fibrosis Cystic Fibrosis - metabolism Electrophysiology Epithelium - drug effects Epithelium - metabolism Humans Iodine - metabolism Iodine Radioisotopes multifunctional calcium/calmodulin‐dependent protein kinase P1 purinoceptor Phenotype Purinergic P1 Receptor Antagonists Receptors, Purinergic P1 - drug effects Receptors, Purinergic P1 - metabolism Signal Transduction - drug effects Spectrometry, Fluorescence Theobromine - analogs & derivatives Theobromine - antagonists & inhibitors Theobromine - pharmacology
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