Actions of two new antagonists showing selectivity for different sub‐types of metabotropic glutamate receptor in the neonatal rat spinal cord

1 The presynaptic depressant action of l‐2‐amino‐4‐phosphonobutyrate (l‐AP4) on the monosynaptic excitation of neonatal rat motoneurones has been differentiated from the similar effects produced by (1S,3R)‐1‐aminocyclopentane‐1,3‐dicarboxylate ((1S,3R)‐ACPD), (1S,3S)‐ACPD and (2S,3S,4S)‐α‐(carboxycy...

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Veröffentlicht in:	British journal of pharmacology 1994-07, Vol.112 (3), p.809-816
Hauptverfasser:	Jane, D.E., Jones, P.L.St.J., Pook, P.C‐K., Tse, H‐W., Watkins, J.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	(1S,3R)‐ACPD (1S,3S)‐ACPD Amino Acids, Dicarboxylic - pharmacology Aminobutyrates - pharmacology Animals Animals, Newborn - physiology antagonism Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cycloleucine - analogs & derivatives Cycloleucine - pharmacology Excitatory amino acids Excitatory Amino Acids - pharmacology Fundamental and applied biological sciences. Psychology In Vitro Techniques l‐AP4 l‐CCG‐I MAP4 MCCG metabotropic glutamate receptors Motor Neurons - drug effects N-Methylaspartate - pharmacology neonatal rat Neurons, Afferent - drug effects Neurotoxins - pharmacology Rats Receptors, Metabotropic Glutamate - antagonists & inhibitors spinal cord Spinal Cord - drug effects Synapses - drug effects Vertebrates: nervous system and sense organs α‐methyl amino acids
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