The pharmacological properties of Y‐23684, a benzodiazepine receptor partial agonist

1 The pharmacological properties of a benzodiazepine receptor (BZR) partial agonist, Y‐23684 were investigated in comparison with those of diazepam, a conventional BZR full agonist. 2 Y‐23684 and diazepam showed high and selective affinity for the BZR with Ki values of 41 and 5.8 nm, respectively. 3...

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Veröffentlicht in:	British journal of pharmacology 1994-04, Vol.111 (4), p.1170-1178
Hauptverfasser:	Yasumatsu, Hiroshi, Morimoto, Yasuto, Yamamoto, Yoshinobu, Takehara, Shuzo, Fukuda, Takemi, Nakao, Tohru, Setoguchi, Michihide
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - pharmacology Anticonvulsants - pharmacology benzodiazepine receptor partial agonist Benzothiepins - metabolism Benzothiepins - pharmacology Biological and medical sciences diazepam elevated plus‐maze test exploration test Exploratory Behavior - drug effects Geller‐Seifter test Male Medical sciences Mice Motor Activity - drug effects Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Pyridazines - metabolism Pyridazines - pharmacology Rats Rats, Wistar Receptors, GABA-A - drug effects Rodentia social interaction test water‐lick test Y‐23684
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